Bus Tickets from Jefferson City, MO to Chicago

Next departures

Next departures for Jefferson City to Chicago on October 2
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Jefferson City
537-517 W. Jackson BlvdCheapest
Greyhound Lines, Inc. + FlixBus
Jefferson City
Chicago 95Th & Dan RyanFastest
Greyhound Lines, Inc. + FlixBus
Jefferson City
Downtown Greyhound StationNo tags

Last refresh of the prices: Yesterday at 9:07 PM CDT.

Accepted payments

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Compare 2 ways to go from Jefferson City to Chicago

Bus
Average PriceUS$40 - US$106Average Duration10h 30m
13kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$49 - US$147Average Duration8h 11m
48kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Jefferson City to Chicago

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 8 hours 11 minutes, and with fares starting at just US$49, it presents an excellent value for a comfortable ride.

2train per day
8h 11mAverage Duration
US$49Cheapest ticket
48kgCO₂ emissions

Bus Jefferson City, MO to Chicago: Trip Overview

Average Ticket PriceUS$59
Average Bus Trip Duration10h 30m
Number of daily buses4
Earliest bus departure7:15pm
Distance532 km

Jefferson City to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Jefferson City to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Jefferson City to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from Jefferson City, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Jefferson City, MO - Chicago

  1. What is the travel distance from Jefferson City to Chicago?

    It's about 531 km (329 miles) from Jefferson City to Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-29
US$60
09-30
US$74
Today
US$82
10-02
US$70
10-03
US$46
10-04
US$48
10-05
US$68
10-06
US$56
busbud logoThe cheapest trip from Jefferson City, MO to Chicago was searched and found on Oct 3, 2025 with a price of US$46

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jefferson City, MO to Chicago, as early as possible.

You can expect to pay from US$46 to US$82 for a bus ticket from Jefferson City, MO to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$46 which is on 2025-10-03.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Jefferson City to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Jefferson City to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jefferson City to Chicago.

Make a music playlist for your bus ride from Jefferson City to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Jefferson City, MO by bus?

Bus from Chicago to Jefferson City, MO

You can also go to Chicago by train

Train from Jefferson City, MO to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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