Find coaches from Chicago to Jefferson City, MO

Tomorrow6 Aug
from US$72
Thu7 Aug
from US$70
Fri8 Aug
from US$78
Sat9 Aug
from US$61
Sun10 Aug
from US$61
Mon11 Aug
from US$79
Tue12 Aug
from US$60
Wed13 Aug

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 6 August at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: 7 August at
    Destination city: Jefferson City
    Destination location: Jefferson City
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 6 August at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: 6 August at
    Destination city: Jefferson City
    Destination location: Jefferson City
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 6 August at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: 7 August at
    Destination city: Jefferson City
    Destination location: Jefferson City
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 6 August at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: 6 August at
    Destination city: Jefferson City
    Destination location: Jefferson City
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 6 August at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: 7 August at
    Destination city: Jefferson City
    Destination location: Jefferson City
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to travel from Chicago to Jefferson City

Bus
Average priceUS$43 - US$175Average duration18h 15m
13kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$49 - US$134Average duration7h 46m
48kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Chicago to Jefferson City

Among the sustainable travel choices, the train stands out as a good way to reach Jefferson City. The journey takes about 7 hours 46 minutes and with fares starting at just US$49, it presents an excellent value for a comfortable ride.

1train per day
7h 46mAverage duration
US$49Cheapest ticket
48kgCO₂ emissions

Bus Chicago to Jefferson City, MO: Trip Overview

Average ticket priceUS$68
Average bus trip duration18h 15m
Number of daily buses5
Earliest bus departure00:15
Distance324 miles
Latest bus departure22:30

Chicago to Jefferson City Bus

With Busbud, comparing and booking tickets for a bus from Chicago to Jefferson City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Jefferson City.

Discover how much the bus trip from Chicago to Jefferson City will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Chicago - Jefferson City, MO

  1. How far is Jefferson City from Chicago by coach?

    The journey from Chicago to Jefferson City by coach covers an approximate distance of 329 miles (531 km).

  2. Is there a way to reach Jefferson City from Chicago without flying?

    To travel from Chicago to Jefferson City without flying, you can take the coaches. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
03/08
US$87
04/08
US$70
Today
US$66
06/08
US$65
07/08
US$68
08/08
US$90
09/08
US$56
10/08
US$73
busbud logoThe cheapest trip from Chicago to Jefferson City, MO was searched and found on 9 Aug 2025 with a price of US$56

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Jefferson City, MO as early as possible.

You can expect to pay from US$56 to US$121 for a bus ticket from Chicago to Jefferson City, MO based on the last 2 days. You can expect to find the cheapest price for the trip at US$56, which is on 2025-08-09.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Chicago to Jefferson City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Chicago to Jefferson City.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Chicago to Jefferson City will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Jefferson City.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Chicago by bus?

Bus from Chicago to Jefferson City, MO

You can also go to Jefferson City, MO by train

Train from Chicago to Jefferson City, MO

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

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