Cheap buses leaving Monday
One passenger / one way
- This trip is recommended because it is the: CheapestDeparture time: August 11 atDeparture city: BuffaloDeparture location: Buffalo (BUF) AirportArrival time: August 13 atDestination city: FlorenceDestination location: Florence, SCOperated by: FlixBus
Vehicle: BusDuration: - This trip is recommended because it is the: Fastest
- Departure time: August 11 atDeparture city: BuffaloDeparture location: Niagara Frontier Transportation AuthorityArrival time: August 13 atDestination city: FlorenceDestination location: Florence, SCOperated by: FlixBusVehicle: BusDuration:
Last refresh of the prices: Last Monday at 2:41 PM EDT.
Prices and availability are subject to change.
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Compare 2 ways to go from Buffalo to Florence
Busbud recommends taking the train from Buffalo to FlorenceAmong the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 22 hours 35 minutes, and with fares starting at just US$241, it presents an excellent value for a comfortable ride.
Bus Buffalo, NY to Florence, SC, US: Trip Overview
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Buffalo to Florence Bus
Busbud helps you find a bus from Buffalo to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
Bus service from Buffalo to Florence will be provided by the most trusted bus companies.
From cheap bus tickets to more luxurious buses travelling from Buffalo to Florence, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Buffalo and Florence?
Frequently asked questions on the trip Buffalo, NY - Florence, SC, US
How far is Buffalo from Florence?
The distance covered from Buffalo to Florence is 969 km (601 miles).
What are the departure and arrival locations for buses traveling from Buffalo to Florence?
Buses traveling this route start their trip at Buffalo Airport, in Buffalo, and end it at Florence Bus Station, in Florence.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to Florence, SC, US was searched and found on Aug 11, 2025 with a price of US$174To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to Florence, SC, US, as early as possible.
You can expect to pay from US$174 to US$200 for a bus ticket from Buffalo, NY to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$174 which is on 2025-08-11.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Buffalo and Florence!
Much more than a mere vehicle taking you from Buffalo to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Buffalo to Florence that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Buffalo to Florence, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
What's the cheapest way to go from Buffalo, NY to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Buses Going to Florence
Popular routes in this country
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