Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Florence Station | CheapestFastest | ||||
| Train | Exchange Street Station | Florence Station | No tags | ||||
| Train | Exchange Street Station | Florence Station | No tags | ||||
| Train | Depew Station | Florence Station | No tags |
Last refresh of the prices: Today at 9:43 AM EDT.
Compare 2 ways to go from Buffalo to Florence
Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 22 hours 25 minutes, and with fares starting at just $488, it presents an excellent value for a comfortable ride.
Train companies
Based on 5768 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi‑Fi. Amtrak ticket prices on this trip start at $488
Frequently asked questions about travelling from Buffalo, NY to Florence, SC, US by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Buffalo to Florence?
The cheapest train tickets from Buffalo to Florence start at $488. The average price for this train route is around $488. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from Buffalo to Florence?
The average train trip from Buffalo to Florence takes 22h 25m and covers 969 km. The quickest train gets you there in 22h 25m and is operated by Amtrak.
Which train operators serve the Buffalo to Florence route?
Several major train operators serve this route, with 2 trains available per day.
What are the earliest and latest departure times for the train from Buffalo to Florence?
The earliest train from Buffalo to Florence departs at 4:28am. The latest train departs at 4:45am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to Florence, SC, US was searched and found on Mar 16, 2026 with a price of $491To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to Florence, SC, US, as early as possible.
You can expect to pay from $491 to $1,151 for a train ticket from Buffalo, NY to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $491 which is on 2026-03-18.
