How much is the bus ticket from Buffalo to Florence?

The cheapest bus tickets from Buffalo to Florence start from $202. The average price for this route is around $214. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Buffalo to Florence?

The average bus trip duration from Buffalo to Florence is 1d 5h, covering a distance of 602 miles (970 km). The quickest bus can get you there in 1d 3h and is operated by Greyhound .

Which bus companies service the Buffalo to Florence route?

Several major bus companies operate on this route with 8 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Buffalo to Florence?

The earliest bus departs from Buffalo to Florence at 12:55am. And the latest bus departs at 11:59pm.

What are the CO₂ emissions for the bus trip from Buffalo to Florence?

A bus trip from Buffalo to Florence generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Buffalo to Florence?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 12256 reviews.

Which bus company has the best Wi-Fi from Buffalo to Florence?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Buffalo to Florence?

According to Busbud traveler reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Buffalo to Florence?

According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Buffalo to Florence from $166 | Refundable Tickets

Next bus departures

Next departures for Buffalo to Florence on March 12
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:00pm	Niagara Frontier Transportation Authority	1d 12h	11:45am	Bus station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	10:50am	Buffalo (BUF) Airport	1d	11:45am	Bus station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	10:30am	Niagara Frontier Transportation Authority	1d 1h	11:45am	Bus station	No tags
	Bus	11:00pm	Niagara Frontier Transportation Authority	1d 6h	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus	11:20pm	Buffalo (BUF) Airport	1d 12h	11:45am	Bus station	No tags

Next departures for Buffalo to Florence on March 13
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	11:20pm	Buffalo (BUF) Airport	1d 6h	5:45am	Florence, SC	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	10:50am	Buffalo (BUF) Airport	1d	11:45am	Bus station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	10:30am	Niagara Frontier Transportation Authority	1d 1h	11:45am	Bus station	No tags
	Bus	11:59pm	Niagara Frontier Transportation Authority	1d 5h	5:45am	Florence, SC	No tags
FlixBus + Greyhound Lines, Inc.	Bus	11:59pm	Niagara Frontier Transportation Authority	1d 11h	11:45am	Bus station	No tags

Next departures for Buffalo to Florence on March 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:30am	Niagara Frontier Transportation Authority	1d 1h	11:45am	Bus station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	10:50am	Buffalo (BUF) Airport	1d	11:45am	Bus station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	11:59pm	Niagara Frontier Transportation Authority	1d 11h	11:45am	Bus station	No tags
	Bus	11:59pm	Niagara Frontier Transportation Authority	1d 5h	5:45am	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:55am	Niagara Frontier Transportation Authority	1d 4h	5:45am	Florence, SC	No tags

Next departures for Buffalo to Florence on March 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:59pm	Niagara Frontier Transportation Authority	1d 11h	11:45am	Bus station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	10:50am	Buffalo (BUF) Airport	1d	11:45am	Bus station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	10:30am	Niagara Frontier Transportation Authority	1d 1h	11:45am	Bus station	No tags
	Bus	10:50am	Buffalo (BUF) Airport	1d 13h	12:05am	Florence, SC	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:55am	Niagara Frontier Transportation Authority	1d 4h	5:45am	Florence, SC	No tags

Next departures for Buffalo to Florence on March 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:59pm	Niagara Frontier Transportation Authority	1d 11h	11:45am	Bus station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	10:50am	Buffalo (BUF) Airport	1d	11:45am	Bus station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	10:30am	Niagara Frontier Transportation Authority	1d 1h	11:45am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	11:20pm	Buffalo (BUF) Airport	1d 12h	11:45am	Bus station	No tags

Last refresh of the prices: Last Monday at 9:23 PM EDT.

Compare 2 ways to go from Buffalo to Florence

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 22 hours 25 minutes and with fares starting at just $347, it presents an excellent value for a comfortable ride.

2train per day

22h 25mAverage Duration

601 milesDistance

88kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$202 - $305	Average Duration1d 5h	CO₂ emissions 24kg CO₂e
Train	Average Price$347 - $351	Average Duration22h 25m	CO₂ emissions 88kg CO₂e

Where are the popular stops in Buffalo and Florence?

Stops in Buffalo

A
Buffalo Airport
Visit page
B
Transportation Center
185 Ellicott St, Buffalo, NY 14203, USA
Visit page
C
Exchange Street Station
75 Exchange St, Buffalo, NY 14203, USA
Visit page

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/512,311 reviews

Staff4.2

Timeliness4

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,527 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, Greyhound, BlaBlaCar Bus, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Buffalo, NY to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Buffalo to Florence?
The cheapest bus tickets from Buffalo to Florence start from $202. The average price for this route is around $214. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Buffalo to Florence?
The average bus trip duration from Buffalo to Florence is 1d 5h, covering a distance of 602 miles (970 km). The quickest bus can get you there in 1d 3h and is operated by Greyhound.
Which bus companies service the Buffalo to Florence route?
Several major bus companies operate on this route with 8 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Buffalo to Florence?
The earliest bus departs from Buffalo to Florence at 12:55am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Buffalo to Florence?
A bus trip from Buffalo to Florence generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Buffalo to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12256 reviews.
Which bus company has the best Wi-Fi from Buffalo to Florence?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Buffalo to Florence?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Buffalo to Florence?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

03/10

$193

03/11

$159

Today

$166

03/13

$199

03/14

$252

03/15

$185

03/16

No data

03/17

No data

The cheapest trip from Buffalo, NY to Florence, SC, US was searched and found on Mar 11, 2026 with a price of $159

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to Florence, SC, US, as early as possible.

You can expect to pay from $159 to $271 for a bus ticket from Buffalo, NY to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $185 which is on 2026-03-15.