Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | MLK Transportation Center | Des Moines | No tags | ||||
| Bus | MLK Transportation Center | Des Moines | No tags | ||||
| Bus | MLK Transportation Center | Des Moines | No tags | ||||
| Bus | MLK Transportation Center | Des Moines | No tags | ||||
| Bus | MLK Transportation Center | Des Moines | No tags |
Get from Sioux City to Des Moines
The journey takes about 15 hours 10 minutes and with fares starting at just $173, it presents an excellent value for a comfortable ride.
Where are the popular stops in Sioux City and Des Moines?
Stops in Sioux City
- A
W Maple St
4110 W Maple St, Sioux Falls, SD 57107, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Compare bus companies
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Frequently asked questions about traveling from Sioux City to Des Moines by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Sioux City to Des Moines?
The cheapest bus tickets from Sioux City to Des Moines start from $173. The average price for this route is around $173. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Sioux City to Des Moines?
The average bus trip duration from Sioux City to Des Moines is 15h 10m, covering a distance of 156 miles (252 km). The quickest bus can get you there in 14h 45m and is operated by Jefferson Lines.
Which bus companies service the Sioux City to Des Moines route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Sioux City to Des Moines?
The earliest bus departs from Sioux City to Des Moines at 7:55am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Sioux City to Des Moines?
A bus trip from Sioux City to Des Moines generates an estimated 6 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Sioux City to Des Moines was searched and found on Dec 12, 2025 with a price of $168To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Sioux City to Des Moines, as early as possible.
You can expect to pay from $168 to $168 for a bus ticket from Sioux City to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $168 which is on 2025-12-12.
