Cheap buses leaving Friday
One passenger / one way
- This trip is recommended because it is: Cheapest + Fastest
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Bus Sioux City to Des Moines: Trip Overview
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Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Sioux City to Des Moines Bus
Busbud helps you find a bus from Sioux City to Des Moines. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
Bus service from Sioux City to Des Moines will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Des Moines from Sioux City, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Sioux City and Des Moines?
Frequently asked questions for your trip Sioux City - Des Moines
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Sioux City to Des Moines was searched and found on Aug 11, 2025 with a price of $168To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Sioux City to Des Moines, as early as possible.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Sioux City and Des Moines!
Much more than a mere vehicle taking you from Sioux City to Des Moines, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Sioux City to Des Moines.
Make a music playlist for your bus ride from Sioux City to Des Moines, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
Top traveled bus routes
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Popular Buses Connecting Sioux City
Buses Leaving from Sioux City
- Bus from Sioux City to Chicago
- Bus Sioux City - Des Moines
- Sioux City - Dallas
- Bus from Sioux City to Omaha
- Bus Sioux City - Minneapolis
- Sioux City - Memphis
- Bus from Sioux City to Billings
- Bus Sioux City - Austin
- Sioux City - Kansas City
- Bus from Sioux City to Albert Lea
- Bus Sioux City - Miami
- Sioux City - Sioux Falls
- Bus from Sioux City to Minot
- Bus Sioux City - Clear Lake
- Sioux City - Oklahoma City
Buses Going to Sioux City
- Bus from Monterrey to Sioux City
- Bus Sioux Falls - Sioux City
- Omaha - Sioux City
- Bus from Aberdeen to Sioux City
- Bus Kansas City - Sioux City
- Dallas - Sioux City
- Bus from Oklahoma City to Sioux City
- Bus Bismarck - Sioux City
- Vermillion - Sioux City
- Bus from Vivian to Sioux City
- Bus Milwaukee - Sioux City
- Austin - Sioux City
- Bus from Tulsa to Sioux City
- Bus Minot - Sioux City
- Rapid City - Sioux City
Popular Buses Connecting Des Moines
Buses Leaving from Des Moines
- Bus from Des Moines to Iowa City
- Bus Des Moines - Washington
- Des Moines - Omaha
- Bus from Des Moines to Denver
- Bus Des Moines - Cedar Rapids
- Des Moines - Chicago
- Bus from Des Moines to Minneapolis
- Bus Des Moines - Kansas City
- Des Moines - Madison
- Bus from Des Moines to Davenport
- Bus Des Moines - Del Rio
- Des Moines - Dallas
- Bus from Des Moines to Sioux Falls
- Bus Des Moines - Ames
- Des Moines - Fargo
Buses Going to Des Moines
- Bus from Washington to Des Moines
- Bus Chicago - Des Moines
- Minneapolis - Des Moines
- Bus from Las Vegas to Des Moines
- Bus Staples - Des Moines
- Iowa City - Des Moines
- Bus from Kansas City to Des Moines
- Bus Ames - Des Moines
- Sioux City - Des Moines
- Bus from Greenfield to Des Moines
- Bus Denver - Des Moines
- Omaha - Des Moines
- Bus from St. Louis to Des Moines
- Bus Cedar Rapids - Des Moines
- Dallas - Des Moines