Bus Tickets from Des Moines to Chicago

Next departures

Next departures for Des Moines to Chicago on September 27
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Burlington Trailways
Des Moines
ChicagoCheapest
Burlington Trailways
Des Moines
ChicagoFastest
Greyhound Lines, Inc.
Des Moines (Subway)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc. + FlixBus
Des Moines (Subway)
Chicago 95Th & Dan RyanNo tags
Burlington Trailways
Des Moines
ChicagoNo tags

Last refresh of the prices: Today at 6:33 AM CDT.

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Bus Des Moines to Chicago: Trip Overview

Average ticket price$51
Average bus trip duration11h 35m
Number of daily buses4
Earliest bus departure5:30am
Distance308 miles (496 km)
Latest bus departure11:15pm

Des Moines to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Des Moines to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Des Moines to Chicago from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Des Moines to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Des Moines - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/24
$65
09/25
$65
Today
$56
09/27
$56
09/28
$81
09/29
$45
09/30
$43
10/01
$41
busbud logoThe cheapest trip from Des Moines to Chicago was searched and found on Oct 1, 2025 with a price of $41

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Chicago, as early as possible.

You can expect to pay from $41 to $125 for a bus ticket from Des Moines to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $41 which is on 2025-10-01.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Des Moines to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Des Moines to Chicago, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Chicago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Des Moines to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Des Moines by bus?

Bus from Chicago to Des Moines

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