How much is the bus ticket from Santander to Lyon?

The cheapest bus tickets from Santander to Lyon start from $125. The average price for this route is around $146. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Santander to Lyon?

The average bus trip duration from Santander to Lyon is 19h 55m, covering a distance of 453 miles (730 km). The quickest bus can get you there in 15h 35m and is operated by FlixBus .

Which bus companies service the Santander to Lyon route?

Several major bus companies operate on this route with 1 buses available per day, including services from ALSA , FlixBus .

What is the earliest and latest departure time for the bus from Santander to Lyon?

The earliest bus departs from Santander to Lyon at 9:00am. And the latest bus departs at 8:45pm.

What are the CO₂ emissions for the bus trip from Santander to Lyon?

A bus trip from Santander to Lyon generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Santander to Lyon?

According to Busbud customers, the highest-rated bus company on this route is ALSA , with an average rating of 4.3 out of 5 stars based on 61149 reviews.

Which bus company has the best Wi-Fi from Santander to Lyon?

Based on reviews on Busbud, the bus company ALSA has the best Wi-Fi rating with a score of 3.5.

Which bus company has the most timely service from Santander to Lyon?

According to Busbud traveller reviews, the most timely bus company on this route is ALSA , with a punctuality rating of 4.3 out of 5 stars.

Which bus company has the cleanest buses from Santander to Lyon?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is ALSA , with a cleanliness rating of 4.7 out of 5 stars.

Bus Santander to Lyon from $49 | Refundable Tickets

Previously seen trips

Next departures for Santander to Lyon on January 23
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	6:35pm	Santander (Estacion de Autobuses)	1d	7:05pm	Aéroport LYS	No tags
Bus	6:35pm	Santander (Estacion de Autobuses)	20h 45m	3:20pm	Perrache	No tags
Bus	8:45pm	Santander (Estacion de Autobuses)	19h 14m	3:59pm	Lyon (F)	No tags
Bus	8:45pm	Santander (Estacion de Autobuses)	19h 14m	3:59pm	Lyon (F)	No tags
Bus	6:35pm	Santander (Estacion de Autobuses)	17h 50m	12:25pm	Aéroport LYS	No tags

Compare 2 ways to go from Santander to Lyon

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as the good way to reach Lyon. The journey takes about 19 hours 55 minutes and with fares starting at just $125, it presents an excellent value for a comfortable ride.

1bus per day

19h 55mAverage Duration

453 milesDistance

18kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$125 - $187	Average Duration19h 55m	CO₂ emissions 18kg CO₂e
Carpool	Average Price$83 - $83	Average Duration10h 50m	CO₂ emissions 31kg CO₂e

Where are the popular stops in Santander and Lyon?

Stops in Santander

A
Calle Navas de Tolosa, 2
Calle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
Visit page
B
Santander Airport
Visit page
C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain
D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain
E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain
F
Estación Marítima
39002 Santander, Cantabria, Spain

Stops in Lyon

A
Perrache
Rue de Esplanade, 69002 Lyon, France
Visit page
B
Lyon Airport
Visit page
C
Lyon
8 Rue de la Paix, 69700 Givors, France
D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France
E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France
F
Les Charrières
Les Charrières, 69570 Dardilly, France
Visit page

Compare bus companies

ALSA

4.5/561,200 reviews

Staff4.7

Timeliness4.4

Cleanliness4.7

Wifi3.5

FlixBus

3.5/512,136 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

FR bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Rede Expressos, Trenitalia

Frequently asked questions about traveling from Santander to Lyon by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Santander to Lyon?
The cheapest bus tickets from Santander to Lyon start from $125. The average price for this route is around $146. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santander to Lyon?
The average bus trip duration from Santander to Lyon is 19h 55m, covering a distance of 453 miles (730 km). The quickest bus can get you there in 15h 35m and is operated by FlixBus.
Which bus companies service the Santander to Lyon route?
Several major bus companies operate on this route with 1 buses available per day, including services from ALSA, FlixBus.
What is the earliest and latest departure time for the bus from Santander to Lyon?
The earliest bus departs from Santander to Lyon at 9:00am. And the latest bus departs at 8:45pm.
What are the CO₂ emissions for the bus trip from Santander to Lyon?
A bus trip from Santander to Lyon generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Santander to Lyon?
According to Busbud customers, the highest-rated bus company on this route is ALSA, with an average rating of 4.3 out of 5 stars based on 61149 reviews.
Which bus company has the best Wi-Fi from Santander to Lyon?
Based on reviews on Busbud, the bus company ALSA has the best Wi-Fi rating with a score of 3.5.
Which bus company has the most timely service from Santander to Lyon?
According to Busbud traveller reviews, the most timely bus company on this route is ALSA, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Santander to Lyon?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is ALSA, with a cleanliness rating of 4.7 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/21

$73

01/22

$55

Today

$56

01/24

$56

01/25

No data

01/26

No data

01/27

$56

01/28

No data

The cheapest trip from Santander to Lyon was searched and found on Jan 22, 2026 with a price of $55

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Lyon, as early as possible.

You can expect to pay from $55 to $138 for a bus ticket from Santander to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $56 which is on 2026-01-27.