Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | SANTANDER | LYON | Cheapest | ||||
| Bus | SANTANDER | LYON | Fastest |
Last refresh of the prices: Last Thursday at 20:25 CET.
Compare 2 ways to travel from Santander to Lyon
Among the sustainable travel choices, the carpool stands out as a good way to reach Lyon. The journey takes about 10 hours 50 minutes and with fares starting at just £64, it presents an excellent value for a comfortable ride.
| Average price | Average duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average price£64 - £141 | Average duration19h 55m | 19kg CO₂e | ||
Carpool | Average price£64 - £64 | Average duration10h 50m | 31kg CO₂e |
Where are the popular stops in Santander and Lyon?
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Lyon
- BRue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Compare bus companies
Frequently asked questions about travelling by bus from Santander to Lyon
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Santander to Lyon?
The cheapest coach tickets from Santander to Lyon start from £64. The average price for this route is around £111. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Santander to Lyon?
The average bus journey time from Santander to Lyon is 19h 55m, covering a distance of 464 miles. The fastest bus can take you there in 15h 35m and is operated by FlixBus.
Which bus companies service the Santander to Lyon route?
What is the earliest and latest departure time for the bus from Santander to Lyon?
The earliest bus departs from Santander to Lyon at 09:00. And the latest bus departs at 20:45.
What are the CO₂ emissions for the bus trip from Santander to Lyon?
A bus journey from Santander to Lyon produces an estimated 19 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Santander to Lyon?
According to Busbud customers, the highest-rated bus company on this route is ALSA, with an average rating of 4.3 out of 5 stars based on 60868 reviews.
Which company has the best Wi-Fi from Santander to Lyon?
Based on Busbud reviews, the bus company ALSA has the best Wi-Fi rating with a score of 3.5.
Which bus company offers the most punctual service from Santander to Lyon?
According to Busbud traveller reviews, the most punctual bus company on this route is ALSA, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Santander to Lyon?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is ALSA, with a cleanliness rating of 4.7 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Lyon was searched and found on 12 Dec 2025 with a price of £45To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Lyon as early as possible.
You can expect to pay from £45 to £106 for a bus ticket from Santander to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at £45, which is on 2025-12-12.
