How much is the bus ticket from Port Saint Lucie to Gainesville?

The cheapest bus tickets from Port Saint Lucie to Gainesville start from $49. The average price for this route is around $77. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Port Saint Lucie to Gainesville?

The average bus trip duration from Port Saint Lucie to Gainesville is 8h, covering a distance of 201 miles (324 km). The quickest bus can get you there in 9h 45m and is operated by FlixBus .

Which bus companies service the Port Saint Lucie to Gainesville route?

Several major bus companies operate on this route with 4 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Port Saint Lucie to Gainesville?

The earliest bus departs from Port Saint Lucie to Gainesville at 1:40am. And the latest bus departs at 8:55am.

What are the CO₂ emissions for the bus trip from Port Saint Lucie to Gainesville?

A bus trip from Port Saint Lucie to Gainesville generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Port Saint Lucie to Gainesville?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11380 reviews.

Which bus company has the best Wi-Fi from Port Saint Lucie to Gainesville?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Port Saint Lucie to Gainesville?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Port Saint Lucie to Gainesville?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Port Saint Lucie to Gainesville from $41 | Refundable Tickets

Previously seen trips

Next departures for Port Saint Lucie to Gainesville on December 2
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	1:40am	Port St Lucie (Park & Ride)	9h 45m	11:25am	Rosa Parks Station	No tags
Greyhound + FlixBus	Bus	1:40am	Port St Lucie (Park & Ride)	6h 10m	7:50am	Gainesville Bus Stop	No tags
	Bus	1:40am	Port St Lucie (Park & Ride)	6h 50m	8:30am	Rosa Parks Station	No tags
FlixBus + Greyhound	Bus	1:40am	Port St Lucie (Park & Ride)	6h 10m	7:50am	Gainesville Bus Stop	No tags
FlixBus + Greyhound	Bus	3:20am	Port St Lucie (Park & Ride)	11h 25m	2:45pm	Gainesville Bus Stop	No tags

Get from Port Saint Lucie to Gainesville

This route is served by bus only

The journey takes about 8 hours and with fares starting at just $49, it presents an excellent value for a comfortable ride.

4bus per day

8hAverage Duration

201 milesDistance

8kgCO₂ emissions

Where are the popular stops in Port Saint Lucie and Gainesville?

Stops in Port Saint Lucie

A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986
Visit page
B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986
C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA
D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953

Stops in Gainesville

A
Rosa Parks Station
700 SE 3rd St, Gainesville, FL 32601
Visit page
B
Williston Rd & I-75
3509 SW Williston Rd, Gainesville, FL 32608, USA
Visit page
C
Greyhound Station
101 NE 23rd Ave, Gainesville, FL 32609
Visit page

Compare bus companies

FlixBus

3.5/511,496 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,412 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Port Saint Lucie to Gainesville, FL by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Port Saint Lucie to Gainesville?
The cheapest bus tickets from Port Saint Lucie to Gainesville start from $49. The average price for this route is around $77. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Port Saint Lucie to Gainesville?
The average bus trip duration from Port Saint Lucie to Gainesville is 8h, covering a distance of 201 miles (324 km). The quickest bus can get you there in 9h 45m and is operated by FlixBus.
Which bus companies service the Port Saint Lucie to Gainesville route?
Several major bus companies operate on this route with 4 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Port Saint Lucie to Gainesville?
The earliest bus departs from Port Saint Lucie to Gainesville at 1:40am. And the latest bus departs at 8:55am.
What are the CO₂ emissions for the bus trip from Port Saint Lucie to Gainesville?
A bus trip from Port Saint Lucie to Gainesville generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Port Saint Lucie to Gainesville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Port Saint Lucie to Gainesville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Port Saint Lucie to Gainesville?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Port Saint Lucie to Gainesville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/30

$116

12/01

$98

Today

No data

12/03

No data

12/04

$41

12/05

No data

12/06

No data

12/07

No data

The cheapest trip from Port Saint Lucie to Gainesville, FL was searched and found on Dec 4, 2025 with a price of $41

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Gainesville, FL, as early as possible.

You can expect to pay from $41 to $167 for a bus ticket from Port Saint Lucie to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $41 which is on 2025-12-04.