Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Südseite Hauptbahnhof | Lampugnano bus station | CheapestFastest | |||||
| Südseite Hauptbahnhof | Milan (Malpensa Aeroporto Terminal 1) | No tags | |||||
Flixtrain + Flixbus | Karlsruhe Hbf | Milan (Malpensa Aeroporto Terminal 1) | No tags | |||||
 | Südseite Hauptbahnhof | Milan Via Giuseppe Impastato | No tags | |||||
| Südseite Hauptbahnhof | Milan (Malpensa Aeroporto Terminal 1) | No tags |
Last refresh of the prices: Yesterday at 3:58 PM CET.
Compare 3 ways to go from Karlsruhe to Milano
Among the sustainable travel choices, the carpool stands out as the good way to reach Milano. The journey takes about 5 hours 50 minutes and with fares starting at just $44, it presents an excellent value for a comfortable ride.
Where are the popular stops in Karlsruhe and Milano?
Stops in Karlsruhe
- AHinterm Hauptbahnhof 6, 76137 Karlsruhe, Germany
- BBahnhofpl. 1A, 76137 Karlsruhe, Germany
- CGoethestraße 17-19, 76135 Karlsruhe, Germany
- D
Karlsruhe
Gartenstraße 58, 76135 Karlsruhe, Germany - E
Karlsruhe/Baden-Baden Airport
Quebec Avenue, 77836 Rheinmünster, Germany
Stops in Milano
- AVia Giulio Natta, 228, 20151 Milano, Italy
- CPiazza I Maggio, 1, 20099 Sesto San Giovanni MI, Italy
- EVia Giuseppe Impastato, 27, 20138 Milano, Italy
- F
Molino Dorino
Molino Dorino, 20151 Milano, Italy
Compare bus companies
Frequently asked questions about traveling from Karlsruhe to Milano by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Karlsruhe to Milano?
The cheapest bus tickets from Karlsruhe to Milano start from $34. The average price for this route is around $50. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Karlsruhe to Milano?
The average bus trip duration from Karlsruhe to Milano is 8h 55m, covering a distance of 244 miles (394 km). The quickest bus can get you there in 7h 20m and is operated by FlixBus.
Which bus companies service the Karlsruhe to Milano route?
Several major bus companies operate on this route with 4 buses available per day, including services from FlixBus, BlaBlaCar Bus, MarinoBus.
What is the earliest and latest departure time for the bus from Karlsruhe to Milano?
The earliest bus departs from Karlsruhe to Milano at 12:25am. And the latest bus departs at 11:40pm.
What are the CO₂ emissions for the bus trip from Karlsruhe to Milano?
A bus trip from Karlsruhe to Milano generates an estimated 10 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Karlsruhe to Milano?
According to Busbud customers, the highest-rated bus company on this route is MarinoBus, with an average rating of 4.1 out of 5 stars based on 893 reviews.
Which bus company has the best Wi-Fi from Karlsruhe to Milano?
Based on reviews on Busbud, the bus company MarinoBus has the best Wi-Fi rating with a score of 3.2.
Which bus company has the most timely service from Karlsruhe to Milano?
According to Busbud traveller reviews, the most timely bus company on this route is MarinoBus, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Karlsruhe to Milano?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is MarinoBus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Karlsruhe to Milano was searched and found on Dec 1, 2025 with a price of $32To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Milano, as early as possible.
You can expect to pay from $32 to $119 for a bus ticket from Karlsruhe to Milano based on the last 2 days. You can expect to find the cheapest price for the trip at $32 which is on 2025-12-01.
Usually BlaBlaCar Bus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
