Bus Tickets from Gainesville, FL to Key West

Next departures

Next departures for Gainesville to Key West on September 22
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Rosa Parks Station
Key West Bus StationCheapestFastest
Greyhound Lines, Inc.
Gainesville Bus Stop
Key West Bus StationNo tags
FlixBus + Greyhound Lines, Inc.
Rosa Parks Station
Key West Bus StationNo tags

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Bus Gainesville, FL to Key West: Trip Overview

Average ticket price$71
Average bus trip duration15h 25m
Number of daily buses4
Earliest bus departure12:35am
Distance358 miles (577 km)
Latest bus departure10:40pm

Gainesville to Key West Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Key West is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Gainesville to Key West will be provided by the most trusted bus companies.

Discover how much the bus trip from Gainesville to Key West will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Gainesville, FL - Key West

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/20
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09/21
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Today
$50
09/23
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09/24
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09/25
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09/26
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busbud logoThe cheapest trip from Gainesville, FL to Key West was searched and found on Sep 22, 2025 with a price of $50

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Key West, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Gainesville to Key West.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Gainesville to Key West, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Gainesville to Key West will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Gainesville to Key West while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Gainesville, FL by bus?

Bus from Key West to Gainesville, FL

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