Compare 2 ways to go from Charleston to Gainesville.
Busbud recommends taking the train from Charleston to GainesvilleAmong the sustainable travel choices, the train stands out as the good way to reach Gainesville. The journey takes about 13 hours 13 minutes and with fares starting at just $72, it presents an excellent value for a comfortable ride.
Bus Charleston, SC, US to Gainesville, FL: Trip Overview
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Charleston to Gainesville Bus
With Busbud, comparing and booking tickets for a bus from Charleston to Gainesville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Charleston to Gainesville from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses traveling from Charleston to Gainesville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Charleston and Gainesville?
Frequently asked questions for your trip Charleston, SC, US - Gainesville, FL
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Charleston, SC, US to Gainesville, FL was searched and found on Aug 8, 2025 with a price of $94To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to Gainesville, FL, as early as possible.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Charleston to Gainesville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Charleston to Gainesville, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Charleston to Gainesville that are otherwise impossible to come by with a plane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Charleston to Gainesville.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
Top traveled bus routes
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Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Charleston
Buses Leaving from Charleston
- Bus from Charleston to Baltimore
- Bus Charleston - Atlanta
- Charleston - Tulsa
- Bus from Charleston to Fort Worth
- Bus Charleston - Miami
- Charleston - Jacksonville
- Bus from Charleston to Savannah
- Bus Charleston - Greenville
- Charleston - Charlotte
- Bus from Charleston to Orlando
- Bus Charleston - New York City
- Charleston - Florence
- Bus from Charleston to Raleigh
- Bus Charleston - Wilmington
- Charleston - Washington
Buses Going to Charleston
- Bus from Baltimore to Charleston
- Bus Boston - Charleston
- Greenville - Charleston
- Bus from Greenville to Charleston
- Bus Raleigh - Charleston
- Nashville - Charleston
- Bus from Savannah to Charleston
- Bus Atlanta - Charleston
- Orlando - Charleston
- Bus from New York City to Charleston
- Bus Charlotte - Charleston
- Miami - Charleston
- Bus from Jacksonville to Charleston
- Bus Washington - Charleston
- Tampa - Charleston
Popular Buses Connecting Gainesville
Buses Leaving from Gainesville
- Bus from Gainesville to Gainesville
- Bus Gainesville - Tampa
- Gainesville - Miami
- Bus from Gainesville to Meridian
- Bus Gainesville - Orlando
- Gainesville - Jacksonville
- Bus from Gainesville to Fort Lauderdale
- Bus Gainesville - Naples
- Gainesville - Atlanta
- Bus from Gainesville to Tallahassee
- Bus Gainesville - West Palm Beach
Buses Going to Gainesville
- Bus from Gainesville to Gainesville
- Bus Jacksonville - Gainesville
- Jacksonville - Gainesville
- Bus from Tampa to Gainesville
- Bus Burlington - Gainesville
- Orlando - Gainesville
- Bus from Miami to Gainesville
- Bus Fort Lauderdale - Gainesville
- Tallahassee - Gainesville
- Bus from Ocala to Gainesville
- Bus Atlanta - Gainesville
- West Palm Beach - Gainesville