Bus from Antofagasta to Santiago, CL: Tickets & Schedules

Next bus departures

Next departures for Antofagasta to Santiago on December 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AndimarBus
    Terminal de Buses Cardenal Carlos Oviedo Cavada)
    Terminal San BorjaCheapest
    Cikbus ElitéBus
    Terminal Antofagasta
    Terminal de Buses San Borja - San Francisco de BorjaFastest
    Cikbus ElitéBus
    Terminal Antofagasta
    Terminal de Buses San Borja - San Francisco de BorjaNo tags
    Pluss ChileBus
    Terminal Antofagasta
    San BorjaNo tags
    Pullman San AndrésBus
    Terminal Carlos Oviedo Cavada
    San BorjaNo tags

    Last refresh of the prices: Today at 12:00 PM -03.

    Get from Antofagasta to Santiago

    This route is served by bus only

    The journey takes about 18 hours 25 minutes and with fares starting at just $27, it presents an excellent value for a comfortable ride.

    50bus per day
    18h 25mAverage Duration
    679 milesDistance
    27kgCO₂ emissions

    Frequently asked questions about traveling from Antofagasta to Santiago, CL by bus

    Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

    1. How much is the bus ticket from Antofagasta to Santiago?

      The cheapest bus tickets from Antofagasta to Santiago start from $27. The average price for this route is around $48. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

    2. How long is the bus ride from Antofagasta to Santiago?

      The average bus trip duration from Antofagasta to Santiago is 18h 25m, covering a distance of 679 miles (1095 km). The quickest bus can get you there in 17h and is operated by Pullman San Andres.

    3. Which bus companies service the Antofagasta to Santiago route?

      Several major bus companies operate on this route with 50 buses available per day, including services from Pluss Chile, Pullman San Andres, Cikbus Elité, Buses Andimar, Clikbus.

    4. What is the earliest and latest departure time for the bus from Antofagasta to Santiago?

      The earliest bus departs from Antofagasta to Santiago at 12:05am. And the latest bus departs at 11:55pm.

    5. What are the CO₂ emissions for the bus trip from Antofagasta to Santiago?

      A bus trip from Antofagasta to Santiago generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

    6. What is the best bus company from Antofagasta to Santiago?

      According to Busbud customers, the highest-rated bus company on this route is Clikbus, with an average rating of 4.3 out of 5 stars based on 3 reviews.

    7. Which bus company has the best Wi-Fi from Antofagasta to Santiago?

      Based on reviews on Busbud, the bus company Pluss Chile has the best Wi-Fi rating with a score of 1.4.

    8. Which bus company has the most timely service from Antofagasta to Santiago?

      According to Busbud traveller reviews, the most timely bus company on this route is Clikbus, with a punctuality rating of 5.0 out of 5 stars.

    9. Which bus company has the cleanest buses from Antofagasta to Santiago?

      According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Buses Andimar, with a cleanliness rating of 4.5 out of 5 stars.

    Find cheapest prices for buses

    Price is for a one-way ticket for one passenger and based on past searches.

    Best price found
    12/01
    $33
    12/02
    $39
    Today
    $34
    12/04
    $34
    12/05
    $33
    12/06
    $26
    12/07
    $26
    12/08
    $33
    busbud logoThe cheapest trip from Antofagasta to Santiago, CL was searched and found on Dec 7, 2025 with a price of $26

    To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, CL, as early as possible.

    You can expect to pay from $26 to $64 for a bus ticket from Antofagasta to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $26 which is on 2025-12-07.

    Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

    People from around the world trust Busbud