Find coaches from San Luis Obispo to San Diego, CA, US

Next departures

Next departures from San Luis Obispo to San Diego on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
Cal Poly Vista Grande Dining Complex
Santa Fe DepotCheapest
Amtrak
Cal Poly Vista Grande Dining Complex
Old Town San DiegoFastest
Amtrak
Cal Poly Vista Grande Dining Complex
Santa Fe DepotNo tags
Amtrak
Cal Poly Vista Grande Dining Complex
Old Town San DiegoNo tags

Last refresh of the prices: Yesterday at 9:23 AM PDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to travel from San Luis Obispo to San Diego

busbud logoWe recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 8 hours 53 minutes and with fares starting at just US$65, it presents an excellent value for a comfortable ride.

5train per day
8h 53mAverage duration
430 kmDistance
39kgCO₂ emissions
Bus
Average priceUS$32 - US$95Average duration10h
11kg CO₂e
Train
Average priceUS$65 - US$130Average duration8h 53m
39kg CO₂e

Bus San Luis Obispo to San Diego, CA, US: Trip Overview

Average ticket priceUS$57
Average bus trip duration10h
Number of daily buses5
Earliest bus departure12:55
Distance431 km
Latest bus departure19:25

San Luis Obispo to San Diego Bus

With Busbud, comparing and booking tickets for a bus from San Luis Obispo to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to San Diego.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from San Luis Obispo, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Luis Obispo - San Diego, CA, US

  1. How much does a bus ticket from San Luis Obispo to San Diego cost?

    The bus ticket price from San Luis Obispo to San Diego starts at US$32. The best way to find cheap bus tickets from San Luis Obispo to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from San Luis Obispo to San Diego?

    The average travel time between San Luis Obispo and San Diego is around 10h, although the fastest bus will take about 8h 45m. This is the time it takes to travel the 426 km that separates the two cities.

  3. How many daily bus connections are there between San Luis Obispo and San Diego?

    The number of buses from San Luis Obispo to San Diego can differ depending on the day of the week. On average, there are 5 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Luis Obispo to San Diego by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from San Luis Obispo to San Diego?

    When taking the bus from San Luis Obispo to San Diego, you can travel comfortably and safely with Amtrak, FlixBus.

  5. What are the departure and arrival stations when taking the bus from San Luis Obispo to San Diego?

    Buses travelling between San Luis Obispo and San Diego leave from AMTRAK Station or San Luis Obispo Bus Stop and arrive at Mission Valley Sheraton, Old Town Courtyard Marriot, Downtown Holiday Inn.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$68
29/10
US$68
Today
US$68
31/10
US$68
01/11
US$68
02/11
US$68
03/11
US$32
04/11
US$31
busbud logoThe cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on 04 Nov 2025 with a price of US$31

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US as early as possible.

You can expect to pay from US$31 to US$119 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$31, which is on 2025-11-04.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Luis Obispo to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Luis Obispo to San Diego.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis Obispo to San Diego.

Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to San Diego while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from San Luis Obispo to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Luis Obispo by bus?

Bus from San Diego, CA, US to San Luis Obispo

You can also go to San Diego, CA, US by train

Train from San Luis Obispo to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting San Luis Obispo

Buses Leaving from San Luis Obispo

Buses Going to San Luis Obispo

Popular Buses Connecting San Diego

Buses Leaving from San Diego

Buses Going to San Diego