Find coaches from San Diego, CA, US to San Luis Obispo

Next departures

Next departures from San Diego to San Luis Obispo on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
Santa Fe Depot
AMTRAK StationCheapest
Greyhound Lines, Inc. + FlixBus
Greyhound Bus Stop
San Luis ObispoFastest
Amtrak
Santa Fe Depot
Cal Poly Vista Grande Dining ComplexNo tags

Last refresh of the prices: Today at 12:58 AM PDT.

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Compare 2 ways to travel from San Diego to San Luis Obispo

busbud logoWe recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach San Luis Obispo. The journey takes about 8 hours 47 minutes and with fares starting at just US$65, it presents an excellent value for a comfortable ride.

5train per day
8h 47mAverage duration
430 kmDistance
39kgCO₂ emissions
Bus
Average priceUS$33 - US$107Average duration12h 40m
11kg CO₂e
Train
Average priceUS$65 - US$127Average duration8h 47m
39kg CO₂e

Bus San Diego, CA, US to San Luis Obispo: Trip Overview

Average ticket priceUS$89
Average bus trip duration12h 40m
Number of daily buses3
Earliest bus departure06:45
Distance431 km
Latest bus departure21:25

San Diego to San Luis Obispo Bus

Busbud helps you find a bus from San Diego to San Luis Obispo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from San Diego to San Luis Obispo will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from San Diego to San Luis Obispo, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - San Luis Obispo

  1. How much does a bus ticket from San Diego to San Luis Obispo cost?

    The bus ticket price from San Diego to San Luis Obispo starts at US$33. The best way to find cheap bus tickets from San Diego to San Luis Obispo is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from San Diego to San Luis Obispo?

    The average travel time between San Diego and San Luis Obispo is around 12h 40m, although the fastest bus will take about 9h 5m. This is the time it takes to travel the 426 km that separates the two cities.

  3. How many daily bus connections are there between San Diego and San Luis Obispo?

    The number of buses from San Diego to San Luis Obispo can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Diego to San Luis Obispo by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from San Diego to San Luis Obispo?

    When taking the bus from San Diego to San Luis Obispo, you can travel comfortably and safely with Amtrak, FlixBus, Greyhound.

  5. What are the departure and arrival stations when taking the bus from San Diego to San Luis Obispo?

    Buses travelling between San Diego and San Luis Obispo leave from Mission Valley Sheraton or Old Town Courtyard Marriot and arrive at AMTRAK Station, San Luis Obispo Bus Stop.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$84
29/10
US$84
Today
US$84
31/10
US$84
01/11
US$84
02/11
US$84
03/11
US$84
04/11
US$84
busbud logoThe cheapest trip from San Diego, CA, US to San Luis Obispo was searched and found on 28 Oct 2025 with a price of US$84

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to San Luis Obispo as early as possible.

You can expect to pay from US$84 to US$84 for a bus ticket from San Diego, CA, US to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at US$84, which is on 2025-10-31.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and San Luis Obispo!

Much more than a mere vehicle taking you from San Diego to San Luis Obispo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to San Luis Obispo that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to San Luis Obispo.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to San Diego, CA, US by bus?

Bus from San Luis Obispo to San Diego, CA, US

You can also go to San Luis Obispo by train

Train from San Diego, CA, US to San Luis Obispo

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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