Find coaches from San Diego, CA, US to St. Louis

Next departures

Next departures from San Diego to St. Louis on 30 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
UCSD Health La Jolla Station
Gateway StationCheapestFastest
FlixBus + Greyhound Lines, Inc.
Downtown SD (Seaport)
Gateway StationNo tags

Last refresh of the prices: Yesterday at 8:04 AM PDT.

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Compare 2 ways to travel from San Diego to St. Louis

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 21 hours 15 minutes and with fares starting at just US$132, it presents an excellent value for a comfortable ride.

6bus per day
1d 21hAverage duration
2514 kmDistance
63kgCO₂ emissions
Bus
Average priceUS$132 - US$431Average duration1d 21h
63kg CO₂e
Train
Average priceUS$202 - US$461Average duration2d 6h
229kg CO₂e

Bus San Diego, CA, US to St. Louis: Trip Overview

Average ticket priceUS$265
Average bus trip duration1d 21h
Number of daily buses6
Earliest bus departure06:45
Distance2514 km
Latest bus departure19:35

San Diego to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Diego to St. Louis.

We make sure you can find a bus service from San Diego to St. Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from San Diego to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - St. Louis

  1. How much does a bus ticket from San Diego to St. Louis cost?

    The bus ticket price from San Diego to St. Louis starts at US$132. The best way to find cheap bus tickets from San Diego to St. Louis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from San Diego to St. Louis?

    The average travel time between San Diego and St. Louis is around 1d 21h, although the fastest bus will take about 1d 19h. This is the time it takes to travel the 2516 km that separates the two cities.

  3. How many daily bus connections are there between San Diego and St. Louis?

    The number of buses from San Diego to St. Louis can differ depending on the day of the week. On average, there are 6 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Diego to St. Louis by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from San Diego to St. Louis?

    When taking the bus from San Diego to St. Louis, you can travel comfortably and safely with Greyhound, FlixBus, Amtrak.

  5. What are the departure and arrival stations when taking the bus from San Diego to St. Louis?

    Buses travelling between San Diego and St. Louis leave from Mission Valley Sheraton or Old Town Courtyard Marriot and arrive at Gateway Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$249
29/10
No data
Today
US$264
31/10
No data
01/11
No data
02/11
No data
03/11
No data
04/11
No data
busbud logoThe cheapest trip from San Diego, CA, US to St. Louis was searched and found on 28 Oct 2025 with a price of US$249

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to St. Louis as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Diego to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to St. Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to St. Louis that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from San Diego, CA, US to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from St. Louis to San Diego, CA, US

You can also go to St. Louis by train

Train from San Diego, CA, US to St. Louis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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