Find coaches from Syracuse, US to St. Louis

Previously seen journeys

Next departures from Syracuse to St. Louis on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
    		Syracuse (Regional Transportation Center)
    		Gateway StationNo tags
    Greyhound + FlixBus
      		Syracuse (Regional Transportation Center)
      		Gateway StationNo tags
      Greyhound
        		Syracuse (Regional Transportation Center)
        		Gateway StationNo tags
        Greyhound
          		Syracuse (Regional Transportation Center)
          		Gateway StationNo tags
          Greyhound
            		Syracuse (Regional Transportation Center)
            		Gateway StationNo tags

            Accepted payments

            • Visa
            • MasterCard
            • American Express
            • China Union Pay
            • Diners Club Canada
            • Discover Click to Pay
            • JCB payment
            • Klarna (Pay over time)
            • Google Pay

            Compare 2 ways to travel from Syracuse to St. Louis

            We recommend taking the train

            Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 22 hours 2 minutes and with fares starting at just US$189, it presents an excellent value for a comfortable ride.

            1train per day
            22h 2mAverage duration
            1278 kmDistance
            116kgCO₂ emissions
            Bus
            		Average priceUS$110 - US$357Average duration1d 3h
            32kg CO₂e
            Train
            		Average priceUS$189 - US$1 102Average duration22h 2m
            116kg CO₂e

            Bus Syracuse, US to St. Louis: Trip Overview

            Average ticket priceUS$165
            Average bus trip duration1d 3h
            Number of daily buses3
            Earliest bus departure04:30
            Distance1278 km
            Latest bus departure21:00

            Syracuse to St. Louis Bus

            With Busbud, comparing and booking tickets for a bus from Syracuse to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            We make sure you can find a bus service from Syracuse to St. Louis from the most reliable bus companies operating this trip.

            Discover how much the bus trip from Syracuse to St. Louis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip Syracuse, US - St. Louis

            1. How much does a bus ticket from Syracuse to St. Louis cost?

              The bus ticket price from Syracuse to St. Louis starts at US$110. The best way to find cheap bus tickets from Syracuse to St. Louis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from Syracuse to St. Louis?

              The average travel time between Syracuse and St. Louis is around 1d 3h, although the fastest bus will take about 1d 2h. This is the time it takes to travel the 1280 km that separates the two cities.

            3. How many daily bus connections are there between Syracuse and St. Louis?

              The number of buses from Syracuse to St. Louis can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Syracuse to St. Louis by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from Syracuse to St. Louis?

              When taking the bus from Syracuse to St. Louis, you can travel comfortably and safely with Greyhound, FlixBus.

            5. What are the departure and arrival stations when taking the bus from Syracuse to St. Louis?

              Buses travelling between Syracuse and St. Louis leave from Regional Transportation Center or Syracuse Airport and arrive at Gateway Station.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            30/10
            US$148
            31/10
            US$193
            Today
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            busbud logoThe cheapest trip from Syracuse, US to St. Louis was searched and found on 30 Oct 2025 with a price of US$148

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to St. Louis as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while travelling from Syracuse to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Syracuse to St. Louis, get comfy and count the stars.

            Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Syracuse to St. Louis will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

            Make a music playlist for your bus ride from Syracuse to St. Louis, and enjoy the scenery to tunes from your own personal soundtrack.

            Did you know?

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            What's the cheapest way to go from Syracuse, US to St. Louis?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to Syracuse, US by bus?

            Bus from St. Louis to Syracuse, US

            You can also go to St. Louis by train

            Train from Syracuse, US to St. Louis

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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