Find coaches from San Diego, CA, US to St. Louis

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Today6 Sept
Tomorrow7 Sept
Mon8 Sept
from US$124
Tue9 Sept
Wed10 Sept
Thu11 Sept
from US$158
Fri12 Sept
Sat13 Sept

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 8 September at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: 10 September at
    Destination city: St. Louis
    Destination location: Saint Louis (Lambert Field)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 8 September at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: 10 September at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 8 September at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: 10 September at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 8 September at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: 10 September at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 8 September at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: 10 September at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to travel from San Diego to St. Louis

Bus
Average priceUS$120 - US$465Average duration2d
63kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$227 - US$1,006Average duration2d 6h
229kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from San Diego to St. Louis

Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 2 days, 45 minutes and with fares starting at just US$120, it presents an excellent value for a comfortable ride.

15bus per day
2d Average duration
US$120Cheapest ticket
63kgCO₂ emissions

Bus San Diego, CA, US to St. Louis: Trip Overview

Average ticket priceUS$168
Average bus trip duration2d
Number of daily buses15
Earliest bus departure07:15
Distance1557 miles
Latest bus departure19:35

San Diego to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Diego to St. Louis.

We make sure you can find a bus service from San Diego to St. Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from San Diego to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - St. Louis

  1. What's the distance between San Diego and St. Louis by coach?

    The distance between San Diego and St. Louis by coach is approximately 1560 miles (2516 km).

  2. How can I travel from San Diego to St. Louis avoiding air travel?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/09
US$154
05/09
US$146
Today
US$154
07/09
No data
08/09
US$119
09/09
No data
10/09
US$174
11/09
US$165
busbud logoThe cheapest trip from San Diego, CA, US to St. Louis was searched and found on 8 Sept 2025 with a price of US$119

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to St. Louis as early as possible.

You can expect to pay from US$119 to US$228 for a bus ticket from San Diego, CA, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$119, which is on 2025-09-08.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Diego to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to St. Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to St. Louis that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from San Diego, CA, US to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from St. Louis to San Diego, CA, US

You can also go to St. Louis by train

Train from San Diego, CA, US to St. Louis

Why choose Busbud?

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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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