Find coaches from San Diego, CA, US to Indianapolis

Previously seen journeys

Next departures from San Diego to Indianapolis on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Greyhound Bus Stop
Downtown Transit CenterNo tags
Greyhound
Greyhound Bus Stop
Indianapolis Bus StationNo tags
Greyhound
Greyhound Bus Stop
Indianapolis Bus StationNo tags
Greyhound + FlixBus
Greyhound Bus Stop
Indianapolis NortheastNo tags
Greyhound + FlixBus
Greyhound Bus Stop
Downtown Transit CenterNo tags

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Compare 2 ways to travel from San Diego to Indianapolis

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 2 days, 6 hours 50 minutes and with fares starting at just US$126, it presents an excellent value for a comfortable ride.

16bus per day
2d 6hAverage duration
2875 kmDistance
72kgCO₂ emissions
Bus
Average priceUS$126 - US$549Average duration2d 6h
72kg CO₂e
Train
Average priceUS$249 - US$388Average duration2d 6h
262kg CO₂e

Bus San Diego, CA, US to Indianapolis: Trip Overview

Average ticket priceUS$202
Average bus trip duration2d 6h
Number of daily buses16
Earliest bus departure06:45
Distance2874 km
Latest bus departure19:35

San Diego to Indianapolis Bus

Busbud helps you find a bus from San Diego to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Diego to Indianapolis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from San Diego to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - Indianapolis

  1. How much does a bus ticket from San Diego to Indianapolis cost?

    The bus ticket price from San Diego to Indianapolis starts at US$126. The best way to find cheap bus tickets from San Diego to Indianapolis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from San Diego to Indianapolis?

    The average travel time between San Diego and Indianapolis is around 2d 6h, although the fastest bus will take about 2d 1h. This is the time it takes to travel the 2876 km that separates the two cities.

  3. How many daily bus connections are there between San Diego and Indianapolis?

    The number of buses from San Diego to Indianapolis can differ depending on the day of the week. On average, there are 16 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Diego to Indianapolis by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from San Diego to Indianapolis?

    When taking the bus from San Diego to Indianapolis, you can travel comfortably and safely with Greyhound, FlixBus, Amtrak.

  5. What are the departure and arrival stations when taking the bus from San Diego to Indianapolis?

    Buses travelling between San Diego and Indianapolis leave from Mission Valley Sheraton or Old Town Courtyard Marriot and arrive at Greyhound Amtrak Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
No data
29/10
US$254
Today
No data
31/10
No data
01/11
No data
02/11
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03/11
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04/11
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busbud logoThe cheapest trip from San Diego, CA, US to Indianapolis was searched and found on 29 Oct 2025 with a price of US$254

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Indianapolis as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and Indianapolis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Indianapolis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Indianapolis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from San Diego, CA, US to Indianapolis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from Indianapolis to San Diego, CA, US

You can also go to Indianapolis by train

Train from San Diego, CA, US to Indianapolis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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