Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Delaware Rest Stop S | Bus station | Cheapest | ||||
 | Bus | Newark (DE) | Florence, SC | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Wilmington Bus Station | Bus station | No tags | ||||
| Bus | Delaware Rest Stop S | Florence, SC | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Wilmington Bus Station | Florence, SC | No tags |
Last refresh of the prices: Yesterday at 21:42 EST.
Compare 2 ways to travel from Wilmington to Florence
Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 10 hours 28 minutes and with fares starting at just £69, it presents an excellent value for a comfortable ride.
Where are the popular stops in Wilmington and Florence?
Stops in Wilmington
- AWilmington Bus Station, 101 N French St, Wilmington, DE 19801, USA
- B100 French St, Wilmington, DE 19801, USA
- C
Wilmington Bus Stop
101 N French , Wilmington, DE 19801
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about travelling by bus from Wilmington, DE to Florence, SC, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Wilmington to Florence?
The cheapest coach tickets from Wilmington to Florence start from £52. The average price for this route is around £76. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Wilmington to Florence?
The average bus journey time from Wilmington to Florence is 18h 25m, covering a distance of 447 miles. The fastest bus can take you there in 12h 55m and is operated by FlixBus.
Which bus companies service the Wilmington to Florence route?
What is the earliest and latest departure time for the bus from Wilmington to Florence?
The earliest bus departs from Wilmington to Florence at 02:55. And the latest bus departs at 21:25.
What are the CO₂ emissions for the bus trip from Wilmington to Florence?
A bus journey from Wilmington to Florence produces an estimated 18 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Wilmington to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12208 reviews.
Which company has the best Wi-Fi from Wilmington to Florence?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Wilmington to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Wilmington to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on 19 Feb 2026 with a price of £114To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US as early as possible.
You can expect to pay from £114 to £139 for a bus ticket from Wilmington, DE to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at £122, which is on 2026-02-20.
What's the cheapest way to go from Wilmington, DE to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
