Find coaches from Lake City to Knoxville, TN

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Tomorrow23 Jun
Tue24 Jun
Wed25 Jun
Thu26 Jun
Fri27 Jun
Sat28 Jun
from US$152
Sun29 Jun
Mon30 Jun

Cheap buses leaving Saturday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 28 June at
    Departure city: Lake City
    Departure location: Lake City Bus Station
    Arrival time: 28 June at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Lake City to Knoxville: Trip Overview

Average ticket priceUS$137
Average bus trip duration12h 15m
Number of daily buses1
Earliest bus departure09:35
Distance407 miles

Lake City to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Lake City to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Lake City to Knoxville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Lake City to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Lake City - Knoxville, TN

  1. How far is Knoxville from Lake City by coach?

    The distance between Lake City and Knoxville by coach is approximately 406 miles (654 km).

  2. Is there a way to reach Knoxville from Lake City without flying?

    You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

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27/06
US$129
busbud logoThe cheapest trip from Lake City to Knoxville was searched and found on 27 Jun 2025 with a price of US$129

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lake City to Knoxville as early as possible.

You can expect to pay from US$129 to US$129 for a bus ticket from Lake City to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at US$129, which is on 2025-06-27.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Lake City to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Lake City to Knoxville, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Lake City to Knoxville will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Lake City to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Lake City by bus?

Bus from Lake City to Knoxville

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