Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pittsburgh Intermodal Station | Winston Salem Greyhound Bus Station | Cheapest | ||||
| Bus | Pittsburgh Intermodal Station | Winston Salem Greyhound Bus Station | Fastest | ||||
| Bus | Pittsburgh Intermodal Station | Winston Salem Greyhound Bus Station | No tags |
Last refresh of the prices: Today at 5:31 AM EST.
Get from Pittsburgh to Winston-Salem
The journey takes about 17 hours 45 minutes, and with fares starting at just $220, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and Winston-Salem?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Stops in Winston-Salem
- A
Winston Salem Greyhound Bus Station
100 W 5th St, Winston Salem, NC 27101 - B
E Sprague St
841 E Sprague St, Winston-Salem, NC 27107, USA - C
Winston-Salem Bus Stop
2500 Old Lexington Rd, Winston-Salem, NC 27107, USA - D
1237 Silas Creek Pkwy
1237 Silas Creek Pkwy., Winston-Salem, NC 27127 (Hong Kong King Buffet)
Compare bus companies
Based on 87519 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at $220
Frequently asked questions about travelling from Pittsburgh to Winston-Salem by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pittsburgh to Winston-Salem?
The cheapest bus tickets from Pittsburgh to Winston-Salem start from $220. The average price for this route is around $225. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to Winston-Salem?
The average bus travel time from Pittsburgh to Winston-Salem is 17h 45m, covering a distance of 484 km. The quickest bus can get you there in 13h 50m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Winston-Salem route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Pittsburgh to Winston-Salem?
The earliest bus departs from Pittsburgh to Winston-Salem at 1:30am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to Winston-Salem?
A bus trip from Pittsburgh to Winston-Salem generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Winston-Salem was searched and found on Feb 4, 2026 with a price of $191To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Winston-Salem, as early as possible.
You can expect to pay from $191 to $198 for a bus ticket from Pittsburgh to Winston-Salem based on the last 2 days. You can expect to find the cheapest price for the trip at $191 which is on 2026-02-04.
