Bus Tickets from Durham, NC, US to Chicago

Find affordable bus tickets from Durham, NC, US to Chicago with flexible options. Book your trip now

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TodayAug 10
TomorrowAug 11
from US$125
TueAug 12
from US$111
WedAug 13
ThuAug 14
from US$123
FriAug 15
from US$141
SatAug 16
from US$122
SunAug 17
from US$126

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 11 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: August 12 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 11 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: August 11 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 11 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: August 11 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 11 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: August 12 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 11 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: August 11 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Last Monday at 12:55 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Frequently asked questions on the trip Durham, NC, US - Chicago

  1. How far is Durham from Chicago?

    The distance between Durham and Chicago is around 999 km (620 miles).

  2. What are the departure and arrival locations for buses traveling from Durham to Chicago?

    Buses traveling this route start their trip at Durham Greyhound Bus Station, in Durham, and end it at Downtown Greyhound Station, in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-08
US$151
08-09
US$143
Today
US$154
08-11
US$117
08-12
US$103
08-13
No data
08-14
US$115
08-15
US$133
busbud logoThe cheapest trip from Durham, NC, US to Chicago was searched and found on Aug 12, 2025 with a price of US$103

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Chicago, as early as possible.

You can expect to pay from US$103 to US$188 for a bus ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$103 which is on 2025-08-12.

Usually FlixBus Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Durham to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Durham to Chicago.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Durham to Chicago that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Durham to Chicago while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Durham, NC, US by bus?

Bus from Durham, NC, US to Chicago

You can also go to Chicago by train

Train from Durham, NC, US to Chicago

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