Find coaches from Durham, NC, US to Chicago

Find affordable coach tickets from Durham, NC, US to Chicago with flexible options. Book your journey now

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Today11 Aug
from US$125
Tomorrow12 Aug
from US$111
Wed13 Aug
Thu14 Aug
from US$123
Fri15 Aug
from US$141
Sat16 Aug
from US$122
Sun17 Aug
from US$126
Mon18 Aug

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 12 August at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: 13 August at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 12 August at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: 12 August at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 12 August at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: 12 August at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 12 August at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: 13 August at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 12 August at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: 12 August at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Frequently asked questions on the trip Durham, NC, US - Chicago

  1. What's the distance between Durham and Chicago by coach?

    The distance between Durham and Chicago by coach is approximately 620 miles (999 km).

  2. How can I travel from Durham to Chicago avoiding air travel?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/08
US$143
10/08
US$154
Today
US$117
12/08
US$103
13/08
No data
14/08
US$115
15/08
US$133
16/08
US$116
busbud logoThe cheapest trip from Durham, NC, US to Chicago was searched and found on 12 Aug 2025 with a price of US$103

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Chicago as early as possible.

You can expect to pay from US$103 to US$188 for a bus ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$103, which is on 2025-08-12.

Usually FlixBus Inc., Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Durham to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Durham to Chicago.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Durham to Chicago that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Durham to Chicago while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Durham, NC, US by bus?

Bus from Durham, NC, US to Chicago

You can also go to Chicago by train

Train from Durham, NC, US to Chicago

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