Bus Tickets from Des Moines to Sioux Falls

Next departures

Next departures for Des Moines to Sioux Falls on October 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson Lines
Des Moines
Sioux FallsCheapestFastest
Jefferson Lines
Des Moines
Sioux FallsNo tags
Jefferson Lines + Land to Air Express
Des Moines
Sioux FallsNo tags
Jefferson Lines
Des Moines
Sioux FallsNo tags

Last refresh of the prices: Last Monday at 11:15 AM CDT.

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Bus Des Moines to Sioux Falls: Trip Overview

Average Ticket PriceUS$173
Average Bus Trip Duration14h 45m
Number of daily buses2
Earliest bus departure3:55am
Distance339 km
Latest bus departure6:30pm

Des Moines to Sioux Falls Bus

With Busbud, comparing and booking tickets for a bus from Des Moines to Sioux Falls is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Des Moines to Sioux Falls will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Sioux Falls from Des Moines, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Des Moines - Sioux Falls

  1. What is the travel distance from Des Moines to Sioux Falls?

    The distance between Des Moines and Sioux Falls is approximately 330 km (205 miles).

  2. What are the departure and arrival locations for buses traveling from Des Moines to Sioux Falls?

    Buses departing from Jefferson/Trailways Depot in Des Moines will take you to Jefferson Lines Station I-29 & Maple St in Sioux Falls.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-30
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10-01
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Today
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10-03
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10-04
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10-05
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10-06
US$121
10-07
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busbud logoThe cheapest trip from Des Moines to Sioux Falls was searched and found on Oct 6, 2025 with a price of US$121

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Sioux Falls, as early as possible.

You can expect to pay from US$121 to US$168 for a bus ticket from Des Moines to Sioux Falls based on the last 2 days. You can expect to find the cheapest price for the trip at US$121 which is on 2025-10-06.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Des Moines to Sioux Falls.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Des Moines to Sioux Falls, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Des Moines to Sioux Falls.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Des Moines to Sioux Falls.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Des Moines by bus?

Bus from Sioux Falls to Des Moines

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