Bus Tickets from Charleston, SC, US to Chicago

Next departures

Next departures for Charleston to Chicago on October 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
4565 Gaynor Ave, North Charleston
Downtown Greyhound StationCheapestFastest
FlixBus + Greyhound Lines, Inc.
4565 Gaynor Ave, North Charleston
537-517 W. Jackson BlvdNo tags
FlixBus
4565 Gaynor Ave, North Charleston
Chicago 95Th & Dan RyanNo tags

Last refresh of the prices: Last Friday at 2:02 PM EDT.

Accepted payments

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Compare 2 ways to go from Charleston to Chicago

Bus
Average PriceUS$90 - US$264Average Duration1d 2h
30kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$231 - US$494Average Duration1d 13h
110kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Charleston to Chicago

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 2 hours 50 minutes, and with fares starting at just US$90, it presents an excellent value for a comfortable ride.

3bus per day
1d 2hAverage Duration
US$90Cheapest ticket
30kgCO₂ emissions

Bus Charleston, SC, US to Chicago: Trip Overview

Average Ticket PriceUS$166
Average Bus Trip Duration1d 2h
Number of daily buses3
Earliest bus departure1:55pm
Distance1206 km
Latest bus departure3:15pm

Charleston to Chicago Bus

Busbud helps you find a bus from Charleston to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Charleston to Chicago.

From cheap bus tickets to more luxurious buses travelling from Charleston to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Charleston, SC, US - Chicago

  1. What is the distance between Charleston and Chicago?

    The distance between Charleston and Chicago is approximately 1218 km (755 miles).

  2. What are the departure and arrival locations for buses traveling from Charleston to Chicago?

    Buses departing from Charleston Bus Station in Charleston will take you to Downtown Greyhound Station in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-27
US$166
09-28
US$158
Today
US$166
09-30
No data
10-01
US$158
10-02
US$159
10-03
No data
10-04
No data
busbud logoThe cheapest trip from Charleston, SC, US to Chicago was searched and found on Sep 28, 2025 with a price of US$158

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to Chicago, as early as possible.

You can expect to pay from US$158 to US$166 for a bus ticket from Charleston, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$158 which is on 2025-10-01.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Charleston and Chicago!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Charleston to Chicago.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Charleston to Chicago that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Charleston to Chicago while indulging in miles on end of beautiful scenic views.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from Charleston, SC, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Charleston, SC, US by bus?

Bus from Chicago to Charleston, SC, US

You can also go to Chicago by train

Train from Charleston, SC, US to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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