Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Big Pine Key, FL | Panama City Beach Station | No tags | ||||
| Bus | Big Pine Key, FL | Panama City Beach Station | No tags | ||||
| Bus | Big Pine Key, FL | Panama City Beach Station | No tags | ||||
| Bus | Big Pine Key, FL | Panama City Beach Station | No tags | ||||
| Bus | Big Pine Key, FL | Panama City Beach Station | No tags |
Get from Big Pine Key to Panama City
This route is served by bus only
The journey takes about 21 hours 20 minutes, and with fares starting at just $205, it presents an excellent value for a comfortable ride.
1bus per day
21h 20mAverage Duration
753 kmDistance
19kgCO₂ emissions
Compare bus companies
3.5 out of 5 stars3.5/587,378 reviews
Based on 87378 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $205
US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Frequently asked questions about travelling from Big Pine Key to Panama City, US by bus
What is the distance between Big Pine Key and Panama City?
The distance covered from Big Pine Key to Panama City is 745 km (462 miles).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-15
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11-16
$140
Today
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11-18
No data
11-19
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11-20
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11-21
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11-22
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The cheapest trip from Big Pine Key to Panama City, US was searched and found on Nov 16, 2025 with a price of $140To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Big Pine Key to Panama City, US, as early as possible.
Top travelled bus routes
People from around the world trust Busbud
Popular Buses Connecting Big Pine Key
Buses Leaving from Big Pine Key
- Bus from Big Pine Key to Baltimore
- Bus Big Pine Key - Fort Myers
- Big Pine Key - Gadsden
- Bus from Big Pine Key to Jacksonville
- Bus Big Pine Key - Miami
- Big Pine Key - Allentown
- Bus from Big Pine Key to Tampa
- Bus Big Pine Key - New York City
- Big Pine Key - Chicago
- Bus from Big Pine Key to West Palm Beach
- Bus Big Pine Key - Atlanta
- Big Pine Key - Spartanburg
- Bus from Big Pine Key to Orlando
- Bus Big Pine Key - Panama City
- Big Pine Key - Charlottesville
Buses Going to Big Pine Key
- Bus from Jacksonville to Big Pine Key
- Bus Miami - Big Pine Key
- Orlando - Big Pine Key
- Bus from Arcadia to Big Pine Key
- Bus Charlottesville - Big Pine Key
- Key West - Big Pine Key
- Bus from Lakeland to Big Pine Key
- Bus West Palm Beach - Big Pine Key
- New York City - Big Pine Key
- Bus from Roanoke to Big Pine Key
- Bus Atlanta - Big Pine Key
- Washington - Big Pine Key
- Bus from Philadelphia to Big Pine Key
- Bus Boston - Big Pine Key
- St. Petersburg - Big Pine Key
Popular Buses Connecting Panama City
Buses Leaving from Panama City
- Bus from Panama City to San Jose
- Bus Panama City - Miami
- Panama City - Atlanta
- Bus from Panama City to Tallahassee
- Bus Panama City - Albany
- Panama City - Orlando
- Bus from Panama City to Morgan City
- Bus Panama City - Kansas City
- Panama City - Alexander City
- Bus from Panama City to Lima
- Bus Panama City - Lake City
- Panama City - New York City
- Bus from Panama City to Indianapolis
- Bus Panama City - Nashville
- Panama City - Albany
Buses Going to Panama City
- Bus from Miami to Panama City
- Bus Atlanta - Panama City
- Tallahassee - Panama City
- Bus from Tampa to Panama City
- Bus Chicago - Panama City
- San Jose - Panama City
- Bus from Cincinnati to Panama City
- Bus Dayton - Panama City
- Fort Myers - Panama City
- Bus from Nashville to Panama City
- Bus Anniston - Panama City
- Tucson - Panama City
- Bus from Orlando to Panama City
- Bus Titusville - Panama City
- Raceland - Panama City
Popular routes in this country
- Bus from Washington to New York City
- Bus Boston - New York City
- New York City - Boston
- Bus from Niagara Falls to New York City
- Bus Philadelphia - New York City
- Buffalo - New York City
- Bus from New York City to Fleischmanns
- Bus Baton Rouge - New Orleans
- Baltimore - New York City
- Bus from Atlanta to Savannah
- Bus Albany - New York City
- New York City - Burlington
- Bus from Detroit to Chicago
- Bus Las Vegas - Los Angeles
- Los Angeles - San Diego