Trains tickets from Harrisburg to Florence, SC, US

Discover your next train travel journey from Harrisburg to Florence, SC, US and book online with ease

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
SunAug 10
from $308
MonAug 11
TueAug 12
WedAug 13
ThuAug 14
FriAug 15
SatAug 16
SunAug 17

Trains leaving Sunday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: August 10 at
    Departure city: Harrisburg
    Departure location: Harrisburg, PA
    Arrival time: August 11 at
    Destination city: Florence
    Destination location: Florence Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:
  • Departure time: August 10 at
    Departure city: Harrisburg
    Departure location: Harrisburg, PA
    Arrival time: August 11 at
    Destination city: Florence
    Destination location: Florence Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:
  • Departure time: August 10 at
    Departure city: Harrisburg
    Departure location: Harrisburg, PA
    Arrival time: August 11 at
    Destination city: Florence
    Destination location: Florence Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Harrisburg to Florence.

Bus
Average Price$97 - $231Average Duration21h 40m
18kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$178 - $308Average Duration14h 5m
66kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Harrisburg to Florence

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 21 hours 40 minutes and with fares starting at just $97, it presents an excellent value for a comfortable ride.

5bus per day
21h 40mAverage Duration
$97Cheapest ticket
18kgCO₂ emissions

Train Harrisburg to Florence, SC, US: Trip Overview

Please note, this information is subject to change.

Average ticket price$210
Average train trip duration14h 5m
Number of daily trains1
Earliest train departure1:05pm
Distance448 miles (721 km)

Harrisburg to Florence Train

With Busbud, comparing and booking tickets for a train from Harrisburg to Florence is a breeze. Browse through an extensive selection of train fares and train schedules to find the best deals.

Train service from Harrisburg to Florence will be provided by the most trusted companies.

Discover how much the train trip from Harrisburg to Florence will cost you. Use our filters and sorting features to find the cheapest train tickets or high-end trains.

Frequently asked questions for your trip Harrisburg - Florence, SC, US

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/06
No data
08/07
No data
Today
No data
08/09
No data
08/10
$296
08/11
No data
08/12
No data
08/13
No data
busbud logoThe cheapest trip from Harrisburg to Florence, SC, US was searched and found on Aug 10, 2025 with a price of $296

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Harrisburg to Florence, SC, US, as early as possible.

You can expect to pay from $296 to $669 for a train ticket from Harrisburg to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $296 which is on 2025-08-10.

About Train Travel

Train Travel Tips

Taking the fastest trains allows you to travel at speeds greater than 300 km/h. Taking a trip from Harrisburg to Florence is not only much quicker but more comfortable too! You can usually travel directly to the city centre and save time while you're at it.

No matter if you plan to take a regional or high-speed train to Florence, the planet will thank you. You’ll help to protect the beautiful landscapes that will unfold before your very eyes.

With up to 30x less CO2 emissions for your train journey between Harrisburg and Florence, the train is an ecological alternative to flights or personal cars.

Make a music playlist for your train ride from Harrisburg to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

New York holds the record for the most platforms and track numbers in a single station. Grand Central Station in Manhattan is one of the largest rail terminals in the world with more than 44 platforms and 67 tracks to accommodate passengers.

Some trains in Sweden can recover more than a fifth of the energy they use by braking. This is especially true with ore trains as they descend from Narvik to Kiruna.

The magnetic levitation train (Maglev for short) is currently the fastest train in the world. With a speed of 603 km/ h, it is closely followed by the French high-speed train (574.8 km / h) which remains in 2020, the fastest train to date

Will you be returning to Harrisburg by train?

Train from Florence, SC, US to Harrisburg

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Trains Connecting Harrisburg

Trains Leaving from Harrisburg

Popular Trains Connecting Florence

Trains Going to Florence