Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Trailways is a network of over 70 bus companies that focus on providing quality bus rides at affordable prices all over the US since 1936. Among the most famous affiliates are Trailways of New York, Pine Hill Trailways, Adirondack Trailways and Burlington Trailways. Trailways buses have WiFi, power outlets, bathrooms, air conditioning, overhead lighting, and reclinable seats with footrests. You can find two different types of Trailway fares: saver and flexible. Saver tickets are non-refundable, while flexible tickets are fully reimbursed up to one hour before travel time. If you're traveling with them, don't forget to print your boarding pass and show a valid photo ID to board the bus.
Based on 1127 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the ticket access and the cleanliness but often complained with the wifi. Adirondack Trailways ticket prices on this trip start at $223
Frequently asked questions about traveling from Syracuse, US to Pittsburgh by bus
What is the distance between Syracuse and Pittsburgh?
The distance between the two cities is 268 miles (432 km).
What are the departure and arrival stations when taking the bus from Syracuse to Pittsburgh?
If you're headed to Pittsburgh from Syracuse, chances are that your bus will depart from Regional Transportation Center and arrive at Intermodal Station. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/24
$105
11/25
$152
Today
$173
11/27
$85
11/28
$117
11/29
$89
11/30
$145
12/01
$89
The cheapest trip from Syracuse, US to Pittsburgh was searched and found on Nov 27, 2025 with a price of $85
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Pittsburgh, as early as possible.
You can expect to pay from $85 to $343 for a bus ticket from Syracuse, US to Pittsburgh based on the last 2 days. You can expect to find the cheapest price for the trip at $85 which is on 2025-11-27.
The cheapest trip from Syracuse, US to Pittsburgh was searched and found on Nov 27, 2025 with a price of $85
