Compare 2 ways to go from St Louis to Harrisburg.
Busbud recommends taking the bus from St Louis to HarrisburgAmong the sustainable travel choices, the bus stands out as the good way to reach Harrisburg. The journey takes about 19 hours 45 minutes and with fares starting at just $107, it presents an excellent value for a comfortable ride.
Bus St Louis to Harrisburg: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
St Louis to Harrisburg Bus
Busbud helps you find a bus from St Louis to Harrisburg. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
Bus service from St Louis to Harrisburg will be provided by the most trusted bus companies.
From cheap bus tickets to more luxurious buses traveling from St Louis to Harrisburg, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in St Louis and Harrisburg?
Frequently asked questions for your trip St Louis - Harrisburg
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St Louis to Harrisburg was searched and found on May 30, 2025 with a price of $99To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to Harrisburg, as early as possible.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St Louis and Harrisburg!
Much more than a mere vehicle taking you from St Louis to Harrisburg, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St Louis to Harrisburg that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from St Louis to Harrisburg while indulging in miles on end of beautiful scenic views.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
What's the cheapest way to go from St Louis to Harrisburg?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.
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