Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Spartanburg | Indianapolis Bus Station | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Spartanburg | Downtown Transit Center | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Spartanburg | Indianapolis Bus Station | No tags | ||||
 | Bus | Spartanburg | Downtown Transit Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Spartanburg | Downtown Transit Center | No tags |
Last refresh of the prices: Today at 12:33 PM EST.
Compare 2 ways to go from Spartanburg to Indianapolis
Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 16 hours 10 minutes and with fares starting at just $119, it presents an excellent value for a comfortable ride.
Where are the popular stops in Spartanburg and Indianapolis?
Stops in Spartanburg
- A9133 Fairforest Rd. Spartanburg, SC , C.P. 29301
- B
Spartanburg Bus Stop
1402 E Main St, Spartanburg, SC 29307, USA - C
Sparta Passenger Center
100 Liberty St, Spartanburg, SC 29306, USA
Compare bus companies
Frequently asked questions about traveling from Spartanburg to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Spartanburg to Indianapolis?
The cheapest bus tickets from Spartanburg to Indianapolis start from $119. The average price for this route is around $155. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Spartanburg to Indianapolis?
The average bus trip duration from Spartanburg to Indianapolis is 16h 10m, covering a distance of 400 miles (645 km). The quickest bus can get you there in 16h 10m and is operated by Greyhound.
Which bus companies service the Spartanburg to Indianapolis route?
What is the earliest and latest departure time for the bus from Spartanburg to Indianapolis?
The earliest bus departs from Spartanburg to Indianapolis at 6:20am. And the latest bus departs at 7:55pm.
What are the CO₂ emissions for the bus trip from Spartanburg to Indianapolis?
A bus trip from Spartanburg to Indianapolis generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Spartanburg to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Spartanburg to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Spartanburg to Indianapolis?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Spartanburg to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Spartanburg to Indianapolis was searched and found on Dec 3, 2025 with a price of $141To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Spartanburg to Indianapolis, as early as possible.
You can expect to pay from $141 to $152 for a bus ticket from Spartanburg to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $141 which is on 2025-12-03.
What's the cheapest way to go from Spartanburg to Indianapolis?
The bus is the cheapest travel choice for this destination
