How far is Santa Fe from Santiago del Estero?

About 341 miles (549 km) separate Santa Fe and Santiago del Estero.

What are the departure and arrival stations when taking the bus from Santa Fe to Santiago del Estero?

Most of the buses traveling from Santa Fe to Santiago del Estero leave from Estación Terminal de Ómnibius, Santa Fe and arrive at Terminal de Ómnibus de Santiago del Estero. These are the main pick-up and drop-off locations on this route, but you can find others that could fit better into your travel plans.

Bus Santa Fe to Santiago del Estero from $29 | Refundable Tickets

Previously seen trips

Next departures for Santa Fe to Santiago del Estero on November 12
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	8:10pm	Estación Terminal de Ómnibius, Santa Fe	9h 45m	5:55am	Terminal de Ómnibus de Santiago del Estero	No tags
Bus	7:50pm	Estación Terminal de Ómnibius, Santa Fe	9h 20m	5:10am	Terminal de Ómnibus de Santiago del Estero	No tags
Bus	7:50pm	Estación Terminal de Ómnibius, Santa Fe	9h 20m	5:10am	Terminal de Ómnibus de Santiago del Estero	No tags
Bus	8:10pm	Estación Terminal de Ómnibius, Santa Fe	9h 45m	5:55am	Terminal de Ómnibus de Santiago del Estero	No tags
Bus	8:10pm	Estación Terminal de Ómnibius, Santa Fe	9h 45m	5:55am	Terminal de Ómnibus de Santiago del Estero	No tags

Get from Santa Fe to Santiago del Estero

This route is served by bus only

The journey takes about 9 hours 20 minutes and with fares starting at just $29, it presents an excellent value for a comfortable ride.

1bus per day

9h 20mAverage Duration

342 milesDistance

14kgCO₂ emissions

Compare bus companies

El Practico

4.5/5556 reviews

Staff4.8

Timeliness4

Cleanliness4.7

Wifi2.4

Flechabus

4/52,112 reviews

Staff4.7

Timeliness3.4

Cleanliness4.1

Wifi1.9

AR bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Santa Fe and Santiago del Estero?

Stops in Santa Fe

A - Estación Terminal de Ómnibius, Santa Fe

Stops in Santiago del Estero

A - Terminal de Ómnibus de Santiago del Estero

B - Terminal Malbran

Frequently asked questions about traveling from Santa Fe, AR to Santiago del Estero by bus

How far is Santa Fe from Santiago del Estero?
What are the departure and arrival stations when taking the bus from Santa Fe to Santiago del Estero?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/10

$27

11/11

No data

Today

No data

11/13

No data

11/14

No data

11/15

No data

11/16

No data

11/17

$29

The cheapest trip from Santa Fe, AR to Santiago del Estero was searched and found on Nov 10, 2025 with a price of $27

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Fe, AR to Santiago del Estero, as early as possible.

You can expect to pay from $27 to $46 for a bus ticket from Santa Fe, AR to Santiago del Estero based on the last 2 days. You can expect to find the cheapest price for the trip at $29 which is on 2025-11-17.