Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal de Ómnibus | Estación Terminal de Ómnibius, Santa Fe | Cheapest | ||||
 | Bus | Terminal de Ómnibus | Estación Terminal de Ómnibius, Santa Fe | Fastest | ||||
| Bus | Terminal de Ómnibus | Estación Terminal de Ómnibius, Santa Fe | No tags | ||||
| Bus | Terminal de Ómnibus | Estación Terminal de Ómnibius, Santa Fe | No tags | ||||
| Bus | Terminal de Ómnibus | Estación Terminal de Ómnibius, Santa Fe | No tags | ||||
| Bus | Terminal de Ómnibus | Estación Terminal de Ómnibius, Santa Fe | No tags |
Last refresh of the prices: Today at 4:46 PM -03.
Get from Puerto Iguazú to Santa Fe
This route is served by bus only
The journey takes about 16 hours 45 minutes and with fares starting at just $75, it presents an excellent value for a comfortable ride.
4bus per day
16h 45mAverage Duration
558 milesDistance
22kgCO₂ emissions
Compare bus companies
4 out of 5 stars4/5569 reviews
3 out of 5 stars3/5260 reviews
4 out of 5 stars4/5584 reviews
AR bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Where are the popular stops in Puerto Iguazú and Santa Fe?
Stops in Puerto Iguazú
Stops in Santa Fe
Frequently asked questions about traveling from Puerto Iguazú to Santa Fe, AR by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/11
No data
11/12
$62
Today
$62
11/14
$62
11/15
No data
11/16
$62
11/17
$62
11/18
$62
The cheapest trip from Puerto Iguazú to Santa Fe, AR was searched and found on Nov 12, 2025 with a price of $62To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Puerto Iguazú to Santa Fe, AR, as early as possible.
You can expect to pay from $62 to $89 for a bus ticket from Puerto Iguazú to Santa Fe, AR based on the last 2 days. You can expect to find the cheapest price for the trip at $62 which is on 2025-11-14.
Usually Rio Uruguay will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
Top traveled bus routes
People from around the world trust Busbud
Popular Buses Connecting Puerto Iguazú
Buses Leaving from Puerto Iguazú
- Bus from Puerto Iguazú to Posadas
- Bus Puerto Iguazú - Foz do Iguaçu
- Puerto Iguazú - Rosario
- Bus from Puerto Iguazú to Córdoba
- Bus Puerto Iguazú - Corrientes
- Puerto Iguazú - Resistencia
- Bus from Puerto Iguazú to San Ignacio
- Bus Puerto Iguazú - Paso de los Libres
- Puerto Iguazú - Wanda
- Bus from Puerto Iguazú to Concordia
- Bus Puerto Iguazú - Santa Fe
- Puerto Iguazú - Puerto Esperanza
- Bus from Puerto Iguazú to Federación
- Bus Puerto Iguazú - Eldorado
- Puerto Iguazú - San Miguel de Tucumán
Buses Going to Puerto Iguazú
- Bus from Posadas to Puerto Iguazú
- Bus Foz do Iguaçu - Puerto Iguazú
- Corrientes - Puerto Iguazú
- Bus from Córdoba to Puerto Iguazú
- Bus Rosario - Puerto Iguazú
- Jardin America - Puerto Iguazú
- Bus from Resistencia to Puerto Iguazú
- Bus Santa Fe - Puerto Iguazú
- Concordia - Puerto Iguazú
- Bus from San Ignacio to Puerto Iguazú
- Bus Wanda - Puerto Iguazú
- Gualeguaychú - Puerto Iguazú
- Bus from El Soberbio to Puerto Iguazú
- Bus El Talar de Pacheco - Puerto Iguazú
- Paraná - Puerto Iguazú
Popular Buses Connecting Santa Fe
Buses Leaving from Santa Fe
- Bus from Santa Fe to America
- Bus Santa Fe - Rosario
- Santa Fe - San Justo
- Bus from Santa Fe to San Justo
- Bus Santa Fe - Villa Ocampo
- Santa Fe - Las Toscas
- Bus from Santa Fe to Buenos Aires
- Bus Santa Fe - Córdoba
- Santa Fe - Puerto Iguazú
- Bus from Santa Fe to San Jorge
- Bus Santa Fe - Reconquista
- Santa Fe - El Colorado
- Bus from Santa Fe to Paso de los Libres
- Bus Santa Fe - Posadas
- Santa Fe - Zarate
Buses Going to Santa Fe
- Bus from Reconquista to Santa Fe
- Bus Vera - Santa Fe
- Franck - Santa Fe
- Bus from Eldorado to Santa Fe
- Bus Avellaneda - Santa Fe
- Torres - Santa Fe
- Bus from Buenos Aires to Santa Fe
- Bus Córdoba - Santa Fe
- Rosario - Santa Fe
- Bus from Puerto Iguazú to Santa Fe
- Bus San Geronimo del Sauce - Santa Fe
- Basail - Santa Fe
- Bus from Pigue to Santa Fe
- Bus Saladillo - Santa Fe
- Resistencia - Santa Fe
Popular routes in this country
- Bus from Buenos Aires to Puerto Iguazú
- Bus El Calafate - Glaciar Perito Moreno
- El Calafate - Perito Moreno
- Bus from El Calafate to San Carlos de Bariloche
- Bus Salta - Cafayate
- Córdoba - Buenos Aires
- Bus from San Carlos de Bariloche to Mendoza
- Bus Puerto Iguazú - Buenos Aires
- Córdoba - Mendoza
- Bus from Mendoza to Salta
- Bus Buenos Aires - Rosario
- Salta - La Quiaca
- Bus from San Carlos de Bariloche to El Chaltén
- Bus Mendoza - Córdoba
- Buenos Aires - San Carlos de Bariloche