How much is the bus ticket from Jacksonville to Florence?

The cheapest bus tickets from Jacksonville to Florence start from $53. The average price for this route is around $69. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Jacksonville to Florence?

The average bus trip duration from Jacksonville to Florence is 5h 35m, covering a distance of 289 miles (465 km). The quickest bus can get you there in 5h 10m and is operated by FlixBus .

Which bus companies service the Jacksonville to Florence route?

Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Jacksonville to Florence?

The earliest bus departs from Jacksonville to Florence at 8:25am. And the latest bus departs at 6:30pm.

What are the CO₂ emissions for the bus trip from Jacksonville to Florence?

A bus trip from Jacksonville to Florence generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Jacksonville to Florence?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11380 reviews.

Which bus company has the best Wi-Fi from Jacksonville to Florence?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Jacksonville to Florence?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Jacksonville to Florence?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Jacksonville to Florence from $45 | Refundable Tickets

Next bus departures

Next departures for Jacksonville to Florence on December 6
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	6:30pm	Jacksonville Bus Station	5h 35m	12:05am	Florence, SC	Cheapest
	Bus	8:25am	Jacksonville Bus Station	5h 10m	1:35pm	Bus station	Fastest

Last refresh of the prices: Last Saturday at 6:11 PM EST.

Compare 2 ways to go from Jacksonville to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 5 hours 35 minutes and with fares starting at just $53, it presents an excellent value for a comfortable ride.

2bus per day

5h 35mAverage Duration

289 milesDistance

12kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$53 - $96	Average Duration5h 35m	CO₂ emissions 12kg CO₂e
Train	Average Price$64 - $145	Average Duration6h 11m	CO₂ emissions 42kg CO₂e

Where are the popular stops in Jacksonville and Florence?

Stops in Jacksonville

A
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA
B
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA
Visit page
C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207
D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/511,490 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,412 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Jacksonville, FL to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Jacksonville to Florence?
The cheapest bus tickets from Jacksonville to Florence start from $53. The average price for this route is around $69. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Jacksonville to Florence?
The average bus trip duration from Jacksonville to Florence is 5h 35m, covering a distance of 289 miles (465 km). The quickest bus can get you there in 5h 10m and is operated by FlixBus.
Which bus companies service the Jacksonville to Florence route?
Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Jacksonville to Florence?
The earliest bus departs from Jacksonville to Florence at 8:25am. And the latest bus departs at 6:30pm.
What are the CO₂ emissions for the bus trip from Jacksonville to Florence?
A bus trip from Jacksonville to Florence generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Jacksonville to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Jacksonville to Florence?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Jacksonville to Florence?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Jacksonville to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/29

$81

11/30

$76

Today

No data

12/02

No data

12/03

No data

12/04

No data

12/05

No data

12/06

$45

The cheapest trip from Jacksonville, FL to Florence, SC, US was searched and found on Dec 6, 2025 with a price of $45

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Florence, SC, US, as early as possible.

You can expect to pay from $45 to $91 for a bus ticket from Jacksonville, FL to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $45 which is on 2025-12-06.