Bus Tickets from Harrisburg to Winston-Salem

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TodayAug 3
TomorrowAug 4
TueAug 5
from $114
WedAug 6
ThuAug 7
from $129
FriAug 8
SatAug 9
SunAug 10

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 5 at
    Departure city: Harrisburg
    Departure location: Harrisburg
    Arrival time: August 6 at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 5 at
    Departure city: Harrisburg
    Departure location: Harrisburg Bus Station
    Arrival time: August 6 at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 5 at
    Departure city: Harrisburg
    Departure location: Harrisburg Bus Station
    Arrival time: August 6 at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 5 at
    Departure city: Harrisburg
    Departure location: Harrisburg Bus Station
    Arrival time: August 6 at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 5 at
    Departure city: Harrisburg
    Departure location: Harrisburg Bus Station
    Arrival time: August 7 at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from Harrisburg to Winston-Salem.

Average Price$116 - $239Average Duration18h 35m
14kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Average Price$271 - $271Average Duration14h 35m
50kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Harrisburg to Winston-Salem

Among the sustainable travel choices, the train stands out as the good way to reach Winston-Salem. The journey takes about 14 hours 35 minutes and with fares starting at just $271, it presents an excellent value for a comfortable ride.

2train per day
14h 35mAverage Duration
$271Cheapest ticket
50kgCO₂ emissions

Bus Harrisburg to Winston-Salem: Trip Overview

Average ticket price$159
Average bus trip duration18h 35m
Number of daily buses6
Earliest bus departure3:05am
Distance340 miles (548 km)
Latest bus departure9:10pm

Harrisburg to Winston-Salem Bus

Busbud helps you find a bus from Harrisburg to Winston-Salem. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Harrisburg to Winston-Salem will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Harrisburg to Winston-Salem, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Harrisburg - Winston-Salem

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/01
No data
08/02
No data
Today
No data
08/04
No data
08/05
$107
08/06
No data
08/07
$122
08/08
No data
busbud logoThe cheapest trip from Harrisburg to Winston-Salem was searched and found on Aug 5, 2025 with a price of $107

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Winston-Salem, as early as possible.

You can expect to pay from $107 to $141 for a bus ticket from Harrisburg to Winston-Salem based on the last 2 days. You can expect to find the cheapest price for the trip at $107 which is on 2025-08-05.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Harrisburg and Winston-Salem!

Much more than a mere vehicle taking you from Harrisburg to Winston-Salem, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Harrisburg to Winston-Salem that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Harrisburg to Winston-Salem.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Harrisburg to Winston-Salem?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Harrisburg by bus?

Bus from Harrisburg to Winston-Salem

You can also go to Winston-Salem by train

Train from Harrisburg to Winston-Salem

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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Popular Buses Connecting Winston-Salem

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