How much is the bus ticket from Durham to Indianapolis?

The cheapest bus tickets from Durham to Indianapolis start from $123. The average price for this route is around $206. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Durham to Indianapolis?

The average bus trip duration from Durham to Indianapolis is 23h 20m, covering a distance of 473 miles (762 km). The quickest bus can get you there in 18h 55m and is operated by FlixBus .

Which bus companies service the Durham to Indianapolis route?

Several major bus companies operate on this route with 9 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Durham to Indianapolis?

The earliest bus departs from Durham to Indianapolis at 1:10am. And the latest bus departs at 10:05pm.

What are the CO₂ emissions for the bus trip from Durham to Indianapolis?

A bus trip from Durham to Indianapolis generates an estimated 19 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Durham to Indianapolis?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11648 reviews.

Which bus company has the best Wi-Fi from Durham to Indianapolis?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Durham to Indianapolis?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Durham to Indianapolis?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Durham to Indianapolis from $115 | Refundable Tickets

Next bus departures

Next departures for Durham to Indianapolis on December 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:05pm	Durham Greyhound Bus Station	20h 35m	6:40pm	Indianapolis Bus Station	Cheapest
	Bus	2:30am	Durham Greyhound Bus Station	18h 55m	9:25pm	Downtown Transit Center	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	3:45am	Durham Greyhound Bus Station	1d	4:00am	Indianapolis Bus Station	No tags
	Bus	9:10am	Durham Greyhound Bus Station	1d	9:45am	Indianapolis Bus Station	No tags
	Bus	8:30am	Durham Greyhound Bus Station	23h 55m	8:25am	Downtown Transit Center	No tags

Last refresh of the prices: Yesterday at 12:07 AM EST.

Compare 2 ways to go from Durham to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 23 hours 20 minutes and with fares starting at just $123, it presents an excellent value for a comfortable ride.

9bus per day

23h 20mAverage Duration

473 milesDistance

19kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$123 - $342	Average Duration23h 20m	CO₂ emissions 19kg CO₂e
Train	Average Price$146 - $869	Average Duration1d 11h	CO₂ emissions 69kg CO₂e

Where are the popular stops in Durham and Indianapolis?

Stops in Durham

A
Durham Greyhound Bus Station
515 W Pettigrew St , Durham, NC 27703
Visit page
B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA
C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA
D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Compare bus companies

FlixBus

3.5/511,712 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,448 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Durham, NC, US to Indianapolis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Durham to Indianapolis?
The cheapest bus tickets from Durham to Indianapolis start from $123. The average price for this route is around $206. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Durham to Indianapolis?
The average bus trip duration from Durham to Indianapolis is 23h 20m, covering a distance of 473 miles (762 km). The quickest bus can get you there in 18h 55m and is operated by FlixBus.
Which bus companies service the Durham to Indianapolis route?
Several major bus companies operate on this route with 9 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Durham to Indianapolis?
The earliest bus departs from Durham to Indianapolis at 1:10am. And the latest bus departs at 10:05pm.
What are the CO₂ emissions for the bus trip from Durham to Indianapolis?
A bus trip from Durham to Indianapolis generates an estimated 19 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Durham to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11648 reviews.
Which bus company has the best Wi-Fi from Durham to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Durham to Indianapolis?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Durham to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/21

No data

12/22

$213

Today

$238

12/24

$150

12/25

$134

12/26

No data

12/27

No data

12/28

No data

The cheapest trip from Durham, NC, US to Indianapolis was searched and found on Dec 25, 2025 with a price of $134

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Indianapolis, as early as possible.

You can expect to pay from $134 to $305 for a bus ticket from Durham, NC, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $134 which is on 2025-12-25.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.