Bus Tickets from Columbia, MO to Chicago

Next departures

Next departures for Columbia to Chicago on September 23
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Midway Truck Plaza Bus Stop
537-517 W. Jackson BlvdCheapest
Greyhound Lines, Inc. + FlixBus
Midway Truck Plaza Bus Stop
Chicago 95Th & Dan RyanFastest
Greyhound Lines, Inc. + FlixBus
Midway Truck Plaza Bus Stop
Downtown Greyhound StationNo tags
Greyhound Lines, Inc. + FlixBus
Midway Truck Plaza Bus Stop
Downtown Greyhound StationNo tags
Greyhound Lines, Inc. + FlixBus
Columbia Wabash Station
Downtown Greyhound StationNo tags

Accepted payments

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Bus Columbia, MO to Chicago: Trip Overview

Average ticket price$58
Average bus trip duration11h 10m
Number of daily buses11
Earliest bus departure8:30am
Distance322 miles (518 km)
Latest bus departure8:35pm

Columbia to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Columbia to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Columbia to Chicago will be provided by the most trusted bus companies.

Discover how much the bus trip from Columbia to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Columbia, MO - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/20
$84
09/21
$81
Today
$65
09/23
$68
09/24
$46
09/25
$68
09/26
$66
09/27
$76
busbud logoThe cheapest trip from Columbia, MO to Chicago was searched and found on Sep 24, 2025 with a price of $46

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbia, MO to Chicago, as early as possible.

You can expect to pay from $46 to $84 for a bus ticket from Columbia, MO to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $46 which is on 2025-09-24.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Columbia to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Columbia to Chicago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Columbia to Chicago will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Columbia to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Will you be returning to Columbia, MO by bus?

Bus from Chicago to Columbia, MO

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