Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Transit Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Transit Center | No tags |
Last refresh of the prices: 02/06/2026 CST.
Get from Tupelo to Indianapolis
The journey takes about 21 hours 10 minutes, and with fares starting at just R 1 369, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87522 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. Greyhound ticket prices on this trip start at R 1 377
Frequently asked questions about travelling from Tupelo to Indianapolis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Tupelo to Indianapolis?
The cheapest bus tickets from Tupelo to Indianapolis start at R 1 369. The average price for this route is around R 1 786. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Tupelo to Indianapolis?
The average bus journey time from Tupelo to Indianapolis is 21h 10m, covering a distance of 655 km. The fastest bus gets you there in 13h 30m and is operated by Greyhound.
Which bus companies service the Tupelo to Indianapolis route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Tupelo to Indianapolis?
The earliest bus departs from Tupelo to Indianapolis at 05:35. And the latest bus departs at 23:15.
What are the CO₂ emissions for the bus trip from Tupelo to Indianapolis?
A bus trip from Tupelo to Indianapolis produces an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Indianapolis was searched and found on 13 Feb 2026 with a price of R 1 652To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Indianapolis as early as possible.
You can expect to pay from R 1 652 to R 2 838 for a bus ticket from Tupelo to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 906, which is on 2026-02-15.
