Find coaches from Tupelo to Indianapolis

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Today10 Jun
Tomorrow11 Jun
from US$153
Thu12 Jun
Fri13 Jun
Sat14 Jun
Sun15 Jun
Mon16 Jun
Tue17 Jun

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 11 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 12 June at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 11 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 12 June at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 11 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 12 June at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 11 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 12 June at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 11 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 12 June at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Tupelo to Indianapolis: Trip Overview

Average ticket priceUS$149
Average bus trip duration21h 10m
Number of daily buses5
Earliest bus departure05:35
Distance406 miles
Latest bus departure23:15

Tupelo to Indianapolis Bus

Busbud helps you find a bus from Tupelo to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Tupelo to Indianapolis.

Whether it is cheap bus tickets or more luxurious buses going to Indianapolis from Tupelo, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Tupelo - Indianapolis

  1. How much is the coach fare from Tupelo to Indianapolis?

    The prices typically range from US$103 to US$239 on this trip, with the average ticket costing US$149. The actual price may differ based on factors like the time you plan to travel, the day of the week, and the coach service provider you select. Keep in mind that booking tickets on the day of travel might result in higher prices.

  2. How long is the coach ride from Tupelo to Indianapolis?

    The coach journey between Tupelo and Indianapolis lasts about 21h 10m. The quickest coach journey typically takes 13h 30m. Please be aware that the time it takes for your journey may vary depending on the traffic conditions along the route.

  3. At what time is the first coach from Tupelo to Indianapolis?

    The first coach to Indianapolis from Tupelo departs at 05:35. Keep in mind that departure times might change on weekends and holidays.

  4. How far is Indianapolis from Tupelo by coach?

    The journey from Tupelo to Indianapolis by coach covers an approximate distance of 406 miles (655 km).

  5. What is the best way to go from Tupelo to Indianapolis without flying?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

  6. Is there am overnight bus from Tupelo to Indianapolis?

    Yes, you can find buses leaving until 23:15 and arriving the next day. Make sure to bring a snack and a blanket to keep yourself feeling comfortable during the night.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/06
No data
09/06
No data
Today
No data
11/06
US$145
12/06
No data
13/06
No data
14/06
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15/06
No data
busbud logoThe cheapest trip from Tupelo to Indianapolis was searched and found on 11 Jun 2025 with a price of US$145

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Indianapolis as early as possible.

You can expect to pay from US$145 to US$175 for a bus ticket from Tupelo to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$145, which is on 2025-06-11.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tupelo and Indianapolis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tupelo to Indianapolis.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tupelo to Indianapolis.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Tupelo by bus?

Bus from Tupelo to Indianapolis

Why choose Busbud?

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