How much does a bus ticket from St. Louis to Chicago cost?

The bus ticket price from St. Louis to Chicago starts at R 607. The best way to find cheap bus tickets from St. Louis to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the bus ride from St. Louis to Chicago?

The average travel time between St. Louis and Chicago is around 6h 25m, although the fastest bus will take about 4h 50m. This is the time it takes to travel the 419 km that separates the two cities.

How many daily bus connections are there between St. Louis and Chicago?

The number of buses from St. Louis to Chicago can differ depending on the day of the week. On average, there are 7 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

Which bus companies travel from St. Louis to Chicago?

When taking the bus from St. Louis to Chicago, you can travel comfortably and safely with FlixBus, Greyhound, Amtrak.

Bus St. Louis to Chicago from R 596 | Refundable Tickets

Next departures

Next departures from St. Louis to Chicago on 17 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags
23:30	Gateway Station	6h 15m	05:45	Downtown Greyhound Station	No tags

Next departures from St. Louis to Chicago on 18 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
08:45	Gateway Station	11h 25m	20:10	Downtown Greyhound Station	No tags
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags

Next departures from St. Louis to Chicago on 19 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
13:55	Gateway Station	9h 5m	23:00	Chicago 95Th & Dan Ryan	CheapestFastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
02:00	Gateway Station	12h 35m	14:35	Downtown Greyhound Station	No tags
08:45	Gateway Station	11h 25m	20:10	Downtown Greyhound Station	No tags
13:55	Gateway Station	9h 40m	23:35	Downtown Greyhound Station	No tags

Next departures from St. Louis to Chicago on 20 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	No tags
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	No tags

Next departures from St. Louis to Chicago on 21 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
23:30	Gateway Station	6h 15m	05:45	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Next departures from St. Louis to Chicago on 22 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
23:30	Gateway Station	6h 15m	05:45	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Next departures from St. Louis to Chicago on 23 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Today at 7:15 PM CST.

Compare 2 ways to travel from St. Louis to Chicago

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 5 minutes and with fares starting at just R 511, it presents an excellent value for a comfortable ride.

4train per day

5h 5mAverage duration

423 kmDistance

38kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceR 607 - R 3 269	Average duration6h 25m	CO₂ emissions 10kg CO₂e
Train	Average priceR 511 - R 4 154	Average duration5h 5m	CO₂ emissions 38kg CO₂e

Compare bus companies

FlixBus

3.5/511 328 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

Greyhound

3.5/587 374 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

According to 27 reviews, Greyhound received a 3.1-star rating for this journey. Travellers were especially satisfied with the temperature and the departure location, but some complained about the value for money. Greyhound ticket prices on this trip start at R 607

Greyhound St. Louis Chicago recent customer reviews

My trip was changed then cancelled and the next bus took 2 hrs . My connection to complete my trip made me arrive at my final destination at 4 am to an empty station where I couldn't get any assistance. Couldn't get a taxi at that hour there. It was a very horrible experience.

Raydell W.

3 July 2023

My first time from along time to many stops little confusing if we were close or what time we really will be in Chicago in all Ok!

Shelia S.

18 July 2019

Very professional and courteous. Actually, quite a bit more professional and less stressful than air travel presently. Pleasantly surprised!

Laura M.

18 October 2018

Amtrak

4/55 586 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

WiFi3.6

Users have praised the service for being on time, comfortable, and convenient with friendly conductors. However, there were concerns about inconsistent behavior from staff towards passengers of different races during ticket checks and upon arrival.

Amtrak St. Louis Chicago recent customer reviews

Smooth ride. The man who did our tickets from St. Louis we noticed after checking white people's tickets he said thanks and have a great day. To black people he said nothing. Then upon arriving in Chicago that man offered no one a hand down or said goodbye.

Yvonne H.

27 September 2024

Fabulous! Train is the way to go for this distance!! On time, comfortable, friendly conductors, and SO convenient!

Kendra H.

3 April 2024

Good but train was cancelled and coming with bus. I pay too much money

Anshul P.

23 December 2024

Burlington Trailways

4/520 reviews

Staff5

Timeliness5

Cleanliness5

WiFi5

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in St. Louis and Chicago?

Stops in St. Louis

A - Gateway Station

Stops in Chicago

A - Downtown Greyhound Station

B - Chicago O'Hare International Airport

C - Polk St & Canal St

D - Tornado Bus S Kedzie Ave

E - Cumberland CTA

F - Turimex California Ave

Frequently asked questions about travelling from St. Louis to Chicago by bus

How much does a bus ticket from St. Louis to Chicago cost?
The bus ticket price from St. Louis to Chicago starts at R 607. The best way to find cheap bus tickets from St. Louis to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from St. Louis to Chicago?
The average travel time between St. Louis and Chicago is around 6h 25m, although the fastest bus will take about 4h 50m. This is the time it takes to travel the 419 km that separates the two cities.
How many daily bus connections are there between St. Louis and Chicago?
The number of buses from St. Louis to Chicago can differ depending on the day of the week. On average, there are 7 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from St. Louis to Chicago?
When taking the bus from St. Louis to Chicago, you can travel comfortably and safely with FlixBus, Greyhound, Amtrak.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

13/11

R 1 121

14/11

R 1 068

Today

R 1 068

16/11

R 998

17/11

R 788

18/11

R 718

19/11

R 692

20/11

R 1 112

The cheapest trip from St. Louis to Chicago was searched and found on 19 Nov 2025 with a price of R 692

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Chicago as early as possible.

You can expect to pay from R 692 to R 5 201 for a bus ticket from St. Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at R 692, which is on 2025-11-19.

Usually Greyhound, Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.