Train from Greenville, SC to Chicago: Tickets & Timetables

Previously seen journeys

Next departures from Greenville to Chicago on 9 December
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags

Compare 2 ways to travel from Greenville to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 21 hours 30 minutes and with fares starting at just £77, it presents an excellent value for a comfortable ride.

13bus per day
21h 30mAverage duration
556 milesDistance
22kgCO₂ emissions
Average price£77 - £367Average duration21h 30m
22kg CO₂e
Average price£136 - £1,637Average duration1d 7h
82kg CO₂e

Frequently asked questions about travelling from Greenville, SC to Chicago by train

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

  1. How much does a train ticket cost from Greenville to Chicago?

    The cheapest train tickets from Greenville to Chicago start from £136. The average price for this train route is around £259. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

  2. How long is the train journey from Greenville to Chicago?

    The average train journey time from Greenville to Chicago is 1d 7h, covering a distance of 561 miles. The fastest train gets you there in 1d 7h and is operated by Amtrak.

  3. Which train operators serve the Greenville to Chicago route?

    Several major train operators run on this route with 1 trains available per day.

  4. What are the earliest and latest departure times for the train from Greenville to Chicago?

    The earliest train from Greenville to Chicago departs at 02:23. And the latest train departs at 02:23.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/12
£232
08/12
No data
Today
£207
10/12
No data
11/12
No data
12/12
No data
13/12
No data
14/12
No data
busbud logoThe cheapest trip from Greenville, SC to Chicago was searched and found on 9 Dec 2025 with a price of £207

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Greenville, SC to Chicago as early as possible.

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