Find coaches from Wilmington, DE to Winston-Salem

Today1 Aug
from US$126
Tomorrow2 Aug
Sun3 Aug
Mon4 Aug
from US$87
Tue5 Aug
Wed6 Aug
Thu7 Aug
Fri8 Aug

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 4 August at
    Departure city: Wilmington
    Departure location: Wilmington Bus Station
    Arrival time: 5 August at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 4 August at
    Departure city: Wilmington
    Departure location: Newark (DE)
    Arrival time: 5 August at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Wilmington
    Departure location: Wilmington Bus Station
    Arrival time: 4 August at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Wilmington
    Departure location: Newark (DE)
    Arrival time: 4 August at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Wilmington
    Departure location: Wilmington Bus Station
    Arrival time: 5 August at
    Destination city: Winston-Salem
    Destination location: Winston Salem Greyhound Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to travel from Wilmington to Winston-Salem

Bus
Average priceUS$87 - US$140Average duration16h 15m
14kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$225 - US$225Average duration11h 15m
52kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Wilmington to Winston-Salem

Among the sustainable travel choices, the train stands out as a good way to reach Winston-Salem. The journey takes about 11 hours 15 minutes and with fares starting at just US$225, it presents an excellent value for a comfortable ride.

2train per day
11h 15mAverage duration
US$225Cheapest ticket
52kgCO₂ emissions

Bus Wilmington, DE to Winston-Salem: Trip Overview

Average ticket priceUS$109
Average bus trip duration16h 15m
Number of daily buses5
Earliest bus departure01:45
Distance358 miles
Latest bus departure21:25

Wilmington to Winston-Salem Bus

Busbud helps you find a bus from Wilmington to Winston-Salem. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Wilmington to Winston-Salem.

From cheap bus tickets to more luxurious buses travelling from Wilmington to Winston-Salem, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Wilmington, DE - Winston-Salem

  1. How far is Winston-Salem from Wilmington by coach?

    The distance between Wilmington and Winston-Salem by coach is approximately 358 miles (577 km).

  2. Is there a way to reach Winston-Salem from Wilmington without flying?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
30/07
No data
31/07
No data
Today
US$125
02/08
No data
03/08
No data
04/08
US$79
05/08
No data
06/08
No data
busbud logoThe cheapest trip from Wilmington, DE to Winston-Salem was searched and found on 4 Aug 2025 with a price of US$79

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Winston-Salem as early as possible.

You can expect to pay from US$79 to US$144 for a bus ticket from Wilmington, DE to Winston-Salem based on the last 2 days. You can expect to find the cheapest price for the trip at US$79, which is on 2025-08-04.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Wilmington and Winston-Salem!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Wilmington to Winston-Salem.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Wilmington to Winston-Salem that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Wilmington to Winston-Salem.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Wilmington, DE to Winston-Salem?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Wilmington, DE by bus?

Bus from Wilmington, DE to Winston-Salem

You can also go to Winston-Salem by train

Train from Wilmington, DE to Winston-Salem

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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