Find coaches from Indianapolis to Charleston, SC, US

Next departures

Next departures from Indianapolis to Charleston on 3 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Downtown Transit Center
4565 Gaynor Ave, North CharlestonCheapestFastest
Greyhound Lines, Inc. + FlixBus
Indianapolis Bus Station
4565 Gaynor Ave, North CharlestonNo tags

Last refresh of the prices: Today at 11:35 EDT.

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Bus Indianapolis to Charleston, SC, US: Trip Overview

Average ticket priceUS$77
Average bus trip duration19h 25m
Number of daily buses2
Earliest bus departure15:50
Distance586 miles
Latest bus departure18:25

Indianapolis to Charleston Bus

Busbud helps you find a bus from Indianapolis to Charleston. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Indianapolis to Charleston will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Indianapolis to Charleston, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Indianapolis - Charleston, SC, US

  1. How far is Charleston from Indianapolis by coach?

    The distance between Indianapolis and Charleston by coach is approximately 594 miles (957 km).

  2. What is the best way to go from Indianapolis to Charleston without flying?

    You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
30/09
No data
01/10
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Today
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03/10
US$149
04/10
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05/10
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06/10
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07/10
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busbud logoThe cheapest trip from Indianapolis to Charleston, SC, US was searched and found on 3 Oct 2025 with a price of US$149

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Charleston, SC, US as early as possible.

You can expect to pay from US$149 to US$149 for a bus ticket from Indianapolis to Charleston, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$149, which is on 2025-10-03.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Indianapolis and Charleston!

Much more than a mere vehicle taking you from Indianapolis to Charleston, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Indianapolis to Charleston that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Indianapolis to Charleston, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Indianapolis by bus?

Bus from Charleston, SC, US to Indianapolis

Why choose Busbud?

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