Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Chicago 95Th & Dan Ryan | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags |
Last refresh of the prices: Last Saturday at 1:21 PM CST.
Get from Tupelo to Chicago
The journey takes about 1 day, 35 minutes, and with fares starting at just $158, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87519 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at $166
Frequently asked questions about travelling from Tupelo to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Chicago?
The cheapest bus tickets from Tupelo to Chicago start from $158. The average price for this route is around $237. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Chicago?
The average bus travel time from Tupelo to Chicago is 1d , covering a distance of 838 km. The quickest bus can get you there in 17h 40m and is operated by Greyhound.
Which bus companies service the Tupelo to Chicago route?
Several major bus companies operate on this route with 9 buses available per day.
What are the earliest and latest departure times for the bus from Tupelo to Chicago?
The earliest bus departs from Tupelo to Chicago at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Chicago?
A bus trip from Tupelo to Chicago generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Chicago was searched and found on Feb 6, 2026 with a price of $156To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago, as early as possible.
You can expect to pay from $156 to $290 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $156 which is on 2026-02-06.
