Bus Tickets from San Luis, AR to Santiago, CL

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TodayJun 14
TomorrowJun 15
MonJun 16
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WedJun 18
from US$61
ThuJun 19
FriJun 20
SatJun 21

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 18 at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: June 18 at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 18 at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: June 18 at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:
  • Departure time: June 18 at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: June 18 at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:

Last refresh of the prices: Last Thursday at 12:56 AM -03.

Prices and availability are subject to change.

Accepted payments

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Bus San Luis to Santiago: Trip Overview

Average Ticket PriceUS$88
Average Bus Trip Duration12h 10m
Number of daily buses1
Earliest bus departure11:20am
Distance407 km

San Luis to Santiago Bus

Busbud helps you find a bus from San Luis to Santiago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Luis to Santiago from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Santiago from San Luis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Luis, AR - Santiago, CL

  1. How long is the bus ride from San Luis to Santiago?

    The typical travel time from San Luis to Santiago by bus is around 12h 10m. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 12h 10m.

  2. How far is San Luis from Santiago?

    It's about 394 km (245 miles) from San Luis to Santiago.

  3. What are the departure and arrival locations for buses traveling from San Luis to Santiago?

    Buses departing from Estación de Interconexión Regional de Ómnibus de San Luis in San Luis will take you to Terminal Sur in Santiago.

  4. What is the cheapest way to travel from San Luis to Santiago?

    The least expensive way to go from San Luis to Santiago would be going by bus. The ticket price for this bus starts at US$88, making this your best choice for this trip.

  5. How much does it cost to take the bus from San Luis to Santiago?

    You can expect to pay around US$88 for the bus ride from San Luis to Santiago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-12
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06-13
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Today
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06-15
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06-16
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06-17
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06-18
US$57
06-19
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busbud logoThe cheapest trip from San Luis to Santiago was searched and found on Jun 18, 2025 with a price of US$57

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis to Santiago, as early as possible.

You can expect to pay from US$57 to US$69 for a bus ticket from San Luis to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$57 which is on 2025-06-18.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Luis and Santiago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Luis to Santiago, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis to Santiago.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Luis to Santiago.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to San Luis by bus?

Bus from San Luis to Santiago

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