Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Fe Depot | Santa Ana Regional Transportation Center | No tags |
Compare 2 ways to go from San Diego to Santa Clara
Among the sustainable travel choices, the train stands out as a good way to reach Santa Clara. The journey takes about 1 hour 54 minutes, and with fares starting at just $45, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 5618 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $45
Frequently asked questions about travelling from San Diego, CA, US to Santa Clara, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Diego to Santa Clara?
The cheapest bus tickets from San Diego to Santa Clara start from $21. The average price for this route is around $21. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to Santa Clara?
The average bus travel time from San Diego to Santa Clara is 2h 5m, covering a distance of 132 km. The quickest bus can get you there in 2h 9m and is operated by Amtrak.
Which bus companies service the San Diego to Santa Clara route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from San Diego to Santa Clara?
The earliest bus departs from San Diego to Santa Clara at 9:25pm. And the latest bus departs at 9:25pm.
What are the CO₂ emissions for the bus trip from San Diego to Santa Clara?
A bus trip from San Diego to Santa Clara generates an estimated 3 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Santa Clara, US was searched and found on Dec 2, 2025 with a price of $155To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Clara, US, as early as possible.
You can expect to pay from $155 to $172 for a bus ticket from San Diego, CA, US to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at $155 which is on 2025-12-02.
What's the cheapest way to go from San Diego, CA, US to Santa Clara, US?
The bus is the cheapest travel choice for this destination
