How far is San Diego from Chicago?

The distance between San Diego and Chicago is approximately 2788 km (1729 miles).

What are the departure and arrival locations for buses traveling from San Diego to Chicago?

Buses departing from Mission Valley Sheraton in San Diego will take you to Downtown Greyhound Station in Chicago.

Bus San Diego to Chicago from $250 | Refundable Tickets

Next bus departures

Next departures for San Diego to Chicago on November 17
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:45pm	Downtown SD (Seaport)	2d 2h	6:35pm	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	12:15pm	San Diego (Old Town-FlixBus)	2d 3h	5:15pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	3:55pm	San Diego (Old Town-FlixBus)	2d 10h	4:10am	Downtown Greyhound Station	No tags

Next departures for San Diego to Chicago on November 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:45pm	Downtown SD (Seaport)	2d 2h	6:35pm	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	2d 6h	4:30pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	9:25am	San Diego (Old Town-FlixBus)	2d 5h	5:15pm	Downtown Greyhound Station	No tags

Next departures for San Diego to Chicago on November 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 2h	6:35pm	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	2d 6h	4:30pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	9:25am	San Diego (Old Town-FlixBus)	2d 5h	5:15pm	Downtown Greyhound Station	No tags

Next departures for San Diego to Chicago on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:45pm	Downtown SD (Seaport)	2d 16h	7:50am	537-517 W. Jackson Blvd	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	2d 6h	4:30pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	9:25am	San Diego (Old Town-FlixBus)	2d 5h	5:15pm	Downtown Greyhound Station	No tags

Next departures for San Diego to Chicago on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	2d 6h	4:30pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 10h	7:50am	537-517 W. Jackson Blvd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	12:15pm	San Diego (Old Town-FlixBus)	2d 3h	5:15pm	Downtown Greyhound Station	No tags

Next departures for San Diego to Chicago on November 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	12:15pm	San Diego (Old Town-FlixBus)	2d 4h	6:35pm	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	2d 6h	4:30pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	12:15pm	San Diego (Old Town-FlixBus)	2d 3h	5:15pm	Downtown Greyhound Station	No tags

Next departures for San Diego to Chicago on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	10:00am	Greyhound Bus Stop	2d 3h	3:55pm	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	2d 6h	4:30pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	12:15pm	San Diego (Old Town-FlixBus)	2d 3h	5:15pm	Downtown Greyhound Station	No tags

Next departures for San Diego to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:45pm	Downtown SD (Seaport)	2d 16h	7:50am	537-517 W. Jackson Blvd	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	2:10pm	UCSD Health La Jolla Station	2d 1h	5:15pm	Downtown Greyhound Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	2d 6h	4:30pm	Downtown Greyhound Station	No tags
	Bus	7:35pm	Greyhound Bus Stop	2d 6h	4:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	12:15pm	San Diego (Old Town-FlixBus)	2d 3h	5:15pm	Downtown Greyhound Station	No tags

Last refresh of the prices: Today at 12:37 AM PST.

Compare 2 ways to go from San Diego to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 2 days, 6 hours 35 minutes, and with fares starting at just $172, it presents an excellent value for a comfortable ride.

33bus per day

2d 6hAverage Duration

2787 kmDistance

70kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$172 - $1,109	Average Duration2d 6h	CO₂ emissions 70kg CO₂e
Train	Average Price$267 - $499	Average Duration1d 22h	CO₂ emissions 254kg CO₂e

Compare bus companies

Greyhound

3.5/587,378 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Amtrak

4/55,591 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

FlixBus

3.5/511,349 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in San Diego and Chicago?

Stops in San Diego

A - Mission Valley Sheraton

B - Old Town Courtyard Marriot

C - Downtown Holiday Inn

D - Greyhound Station

E - Market St. & Park Blvd

F - San Ysidro McDonald's

Stops in Chicago

A - Downtown Greyhound Station

B - Chicago O'Hare International Airport

C - Polk St & Canal St

D - Tornado Bus S Kedzie Ave

E - Cumberland CTA

F - Turimex California Ave

Frequently asked questions about travelling from San Diego, CA, US to Chicago by bus

How far is San Diego from Chicago?
The distance between San Diego and Chicago is approximately 2788 km (1729 miles).
What are the departure and arrival locations for buses traveling from San Diego to Chicago?
Buses departing from Mission Valley Sheraton in San Diego will take you to Downtown Greyhound Station in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-15

$773

11-16

$678

Today

$573

11-18

$638

11-19

$482

11-20

$467

11-21

$445

11-22

$460

The cheapest trip from San Diego, CA, US to Chicago was searched and found on Nov 21, 2025 with a price of $445

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Chicago, as early as possible.

You can expect to pay from $445 to $787 for a bus ticket from San Diego, CA, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $445 which is on 2025-11-21.