Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Isernia | CheapestFastest | ||||
| Bus | Rome Fiumicino Airport | Isernia | No tags | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | Isernia | No tags |
Last refresh of the prices: Last Thursday at 2:44 PM CET.
Compare 3 ways to go from Rome to Isernia
Among the sustainable travel choices, the carpool stands out as a good way to reach Isernia. The journey takes about 2 hours, and with fares starting at just $13, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Isernia?
Stops in Rome
- ALargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Compare bus companies
Based on 11559 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $28
Frequently asked questions about travelling from Rome to Isernia by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Rome to Isernia?
The cheapest bus tickets from Rome to Isernia start from $28. The average price for this route is around $43. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Rome to Isernia?
The average bus travel time from Rome to Isernia is 6h 44m, covering a distance of 167 km. The quickest bus can get you there in 2h 10m and is operated by FlixBus.
Which bus companies service the Rome to Isernia route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Rome to Isernia?
The earliest bus departs from Rome to Isernia at 2:45am. And the latest bus departs at 2:50pm.
What are the CO₂ emissions for the bus trip from Rome to Isernia?
A bus trip from Rome to Isernia generates an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Isernia was searched and found on Dec 12, 2025 with a price of $26To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Isernia, as early as possible.
You can expect to pay from $26 to $83 for a bus ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at $26 which is on 2025-12-12.
