Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
 | Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
| Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
| Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
| Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags |
Get from Port Saint Lucie to Jacksonville
The journey takes about 6 hours 5 minutes, and with fares starting at just $59, it presents an excellent value for a comfortable ride.
Where are the popular stops in Port Saint Lucie and Jacksonville?
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
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Frequently asked questions about travelling from Port Saint Lucie to Jacksonville, FL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Port Saint Lucie to Jacksonville?
The cheapest bus tickets from Port Saint Lucie to Jacksonville start from $59. The average price for this route is around $88. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Port Saint Lucie to Jacksonville?
The average bus travel time from Port Saint Lucie to Jacksonville is 6h 5m, covering a distance of 363 km. The quickest bus can get you there in 6h 5m and is operated by FlixBus.
Which bus companies service the Port Saint Lucie to Jacksonville route?
What are the earliest and latest departure times for the bus from Port Saint Lucie to Jacksonville?
The earliest bus departs from Port Saint Lucie to Jacksonville at 1:40am. And the latest bus departs at 3:45pm.
What are the CO₂ emissions for the bus trip from Port Saint Lucie to Jacksonville?
A bus trip from Port Saint Lucie to Jacksonville generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Port Saint Lucie to Jacksonville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Port Saint Lucie to Jacksonville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Port Saint Lucie to Jacksonville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Port Saint Lucie to Jacksonville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Port Saint Lucie to Jacksonville, FL was searched and found on Dec 5, 2025 with a price of $52To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Jacksonville, FL, as early as possible.
You can expect to pay from $52 to $101 for a bus ticket from Port Saint Lucie to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $52 which is on 2025-12-05.
Top travelled bus routes
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